Academic Journal
Peculiarities of vitamin D metabolism in diabetic kidney disease
| العنوان: | Peculiarities of vitamin D metabolism in diabetic kidney disease |
|---|---|
| المؤلفون: | V.M. Yerokhovych, O.V. Karpenko, I.A. Paliienko, I.V. Dumka, O.A. Rudenko, Iu.I. Komisarenko |
| المصدر: | Počki, Vol 13, Iss 4, Pp 257-260 (2024) |
| بيانات النشر: | Zaslavsky O.Yu., 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | vitamin d, diabetic kidney disease, vitamin d binding protein, sodium-dependent glucose cotransporter-2 inhibitors, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | The analysis of literature revealed the peculiarities of vitamin D metabolism in diabetic kidney damage, as well as its role in the development of renal, metabolic changes, including bone and mineral disorders. Vitamin D, due to its influence on various physiological processes through vitamin D receptors, plays a key role in the regulation of mineral and bone metabolism, the functioning of the immune system and the control of other extraskeletal effects. In patients with diabetic kidney damage, vitamin D deficiency causes impaired hydroxylation and the formation of an active metabolite (1,25(OH)2D3), which leads to the progression of kidney damage, the development of proteinuria and fibrosis. The mechanisms of glucose and vitamin D interaction at the level of the proximal tubules were analyzed, which emphasizes the need for further research to develop therapeutic strategies for correcting vitamin D deficiency in patients with diabetic kidney damage in order to improve their prognosis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Ukrainian |
| تدمد: | 2307-1257 2307-1265 |
| Relation: | https://kidneys.zaslavsky.com.ua/index.php/journal/article/view/481; https://doaj.org/toc/2307-1257; https://doaj.org/toc/2307-1265 |
| DOI: | 10.22141/2307-1257.13.4.2024.481 |
| URL الوصول: | https://doaj.org/article/4af6c961ec8d4f1e8ddf3bad750f9eb1 |
| رقم الانضمام: | edsdoj.4af6c961ec8d4f1e8ddf3bad750f9eb1 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 23071257 23071265 |
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| DOI: | 10.22141/2307-1257.13.4.2024.481 |