Academic Journal
Dosimetric benefit and clinical feasibility of deep inspiration breath-hold and volumetric modulated arc therapy-based postmastectomy radiotherapy for left-sided breast cancer
| العنوان: | Dosimetric benefit and clinical feasibility of deep inspiration breath-hold and volumetric modulated arc therapy-based postmastectomy radiotherapy for left-sided breast cancer |
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| المؤلفون: | Shi-Jia Wang, Yi-Rui Zhai, Wen-Wen Zhang, Si-Ye Chen, Shi-Rui Qin, Hui Fang, Yu Tang, Yong-Wen Song, Yue-Ping Liu, Bo Chen, Shu-Nan Qi, Yuan Tang, Ning-Ning Lu, Ye-Xiong Li, Hao Jing, Shu-Lian Wang |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Left-sided breast cancer, Postmastectomy radiotherapy, Deep inspiratory breath-hold, Cardiopulmonary dose, Setup error, Medicine, Science |
| الوصف: | Abstract To evaluate the dosimetric benefits and clinical feasibility of deep inspiratory breath-hold (DIBH) combined with volumetric modulated arc therapy (VMAT) in left-sided postmastectomy radiotherapy (PMRT). Eligible patients with left-sided breast cancer undergoing DIBH-based PMRT were prospectively included. Chest wall, supra/infraclavicular fossa, and/or internal mammary node irradiation (IMNI) were planned with a prescription dose of 43.5 Gy in 15 fractions. VMAT plans were designed on free breathing (FB)—and DIBH-CT to compare dosimetric parameters in heart, left anterior descending artery (LAD) and lung. Cone-beam computed tomography (CBCT) was performed before and after treatment to evaluate inter- and intra-fractional setup errors. Heart position and dose variations during treatment were estimated by fusing CBCT with DIBH-CT scans.Twenty patients were included with 10 receiving IMNI. In total, 193 pre-treatment and 39 pairs pre- and post-treatment CBCT scans were analyzed. The Dmean, Dmax, and V5−40 of the heart, LAD, and left lung were significantly lower in DIBH than FB (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 33555737 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-75560-5 |
| URL الوصول: | https://doaj.org/article/a49f46bedbfe43c5ae92ac33555737f3 |
| رقم الانضمام: | edsdoj.49f46bedbfe43c5ae92ac33555737f3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 33555737 |
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| DOI: | 10.1038/s41598-024-75560-5 |