Academic Journal
Impact of bosentan therapy on stress-induced pulmonary hypertension in patients with systemic sclerosis
| العنوان: | Impact of bosentan therapy on stress-induced pulmonary hypertension in patients with systemic sclerosis |
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| المؤلفون: | A V Volkov, I A Kurmukov, N N Iudkina, S I Glukhova, E V Nikolaeva |
| المصدر: | Терапевтический архив, Vol 87, Iss 1, Pp 49-56 (2015) |
| بيانات النشر: | "Consilium Medicum" Publishing house, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | pulmonary arterial hypertension, systemic sclerosis, bosentan, exercise-induced pulmonary hypertension, Medicine |
| الوصف: | Aim. To describe hemodynamic and clinical changes in patients with elevated mean pulmonary artery pressure (MPAP) >30 mm Hg during exercise and the impact of bosentan therapy on stress-induced pulmonary hypertension (SIPH). Subjects and methods. The study included 19 patients with systemic sclerosis (SDS) in whom possible causes of pulmonary hypertension (PH) (lung and left heart injuries and thromboembolism) were excluded. All the patients underwent pulmonary artery catheterization at rest and during exercise. The hemodynamic (right atrial pressure (RAP), systolic and diastolic pressure, MPAP, pulmonary artery wedge pressure (PAWP), cardiac output (CO) by a thermodilution technique), clinical (demographic, immunological, and instrumental) parameters were analyzed and the risk of pulmonary arterial hypertension (PAH) was also calculated; 5 patients with SIPH received 16-week bosentan therapy according to the conventional regimen. Results. Ten of the 19 patients were at increased risk for PAH in accordance with the DETECT scale, but no signs of PH at resting catheterization were found in anybody. In 5 patients, MPAP, was in the range from 21 to 24 mm Hg; in 9 (47%) patients were found to have SIPH, a median MPAP of 35 (32; 41) mm Hg. Seven patients had no diagnostic changes during exercise; 3 patients could not perform an exercise test. There were correlations between MPAP and DETECT risk scores (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 0040-3660 2309-5342 |
| Relation: | https://ter-arkhiv.ru/0040-3660/article/view/31676; https://doaj.org/toc/0040-3660; https://doaj.org/toc/2309-5342 |
| URL الوصول: | https://doaj.org/article/4984bc6ef2ac4ddd9dac195dd5964238 |
| رقم الانضمام: | edsdoj.4984bc6ef2ac4ddd9dac195dd5964238 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 00403660 23095342 |
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