Academic Journal
Lamin B1 as a key modulator of the developing and aging brain
| العنوان: | Lamin B1 as a key modulator of the developing and aging brain |
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| المؤلفون: | Foteini-Dionysia Koufi, Irene Neri, Giulia Ramazzotti, Isabella Rusciano, Sara Mongiorgi, Maria Vittoria Marvi, Antonietta Fazio, Minkyung Shin, Yoichi Kosodo, Ilaria Cani, Elisa Giorgio, Pietro Cortelli, Lucia Manzoli, Stefano Ratti |
| المصدر: | Frontiers in Cellular Neuroscience, Vol 17 (2023) |
| بيانات النشر: | Frontiers Media S.A., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: | lamin B1, nuclear lamina, glia, astrocytes, neurogenesis, neurons, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | Lamin B1 is an essential protein of the nuclear lamina that plays a crucial role in nuclear function and organization. It has been demonstrated that lamin B1 is essential for organogenesis and particularly brain development. The important role of lamin B1 in physiological brain development and aging has only recently been at the epicenter of attention and is yet to be fully elucidated. Regarding the development of brain, glial cells that have long been considered as supporting cells to neurons have overturned this representation and current findings have displayed their active roles in neurogenesis and cerebral development. Although lamin B1 has increased levels during the differentiation of the brain cells, during aging these levels drop leading to senescent phenotypes and inciting neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. On the other hand, overexpression of lamin B1 leads to the adult-onset neurodegenerative disease known as Autosomal Dominant Leukodystrophy. This review aims at highlighting the importance of balancing lamin B1 levels in glial cells and neurons from brain development to aging. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1662-5102 64034216 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fncel.2023.1263310/full; https://doaj.org/toc/1662-5102 |
| DOI: | 10.3389/fncel.2023.1263310 |
| URL الوصول: | https://doaj.org/article/4930a394323e4810b2513ff640342165 |
| رقم الانضمام: | edsdoj.4930a394323e4810b2513ff640342165 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16625102 64034216 |
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| DOI: | 10.3389/fncel.2023.1263310 |