التفاصيل البيبلوغرافية
| العنوان: |
A heteropolysaccharide from Rhodiola rosea L.: preparation, purification and anti-tumor activities in H22-bearing mice |
| المؤلفون: |
Yaru Wu, Qing Wang, Huiping Liu, Lulu Niu, Mengyu Li, Qi Jia |
| المصدر: |
Food Science and Human Wellness, Vol 12, Iss 2, Pp 536-545 (2023) |
| بيانات النشر: |
Tsinghua University Press, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Nutrition. Foods and food supply |
| مصطلحات موضوعية: |
Polysaccharide, Antitumor activity, Rhodiola rosea L., Structure analysis, Nutrition. Foods and food supply, TX341-641 |
| الوصف: |
Numerous polysaccharides isolated from plants have been used to augment traditional drugs in the treatment of cancer. In order to explore the influence to hepatocellular carcinoma, a novel cold water-soluble polysaccharide was separated from Rhodiola rosea L. root (RLP) and then its structure and anti-cancer activities were tested. The chemical compositions and high performance gel permeation chromatography (HPGPC) results indicated that RLP was an acid heteropolysaccharide with the molecular weight of about 1.15×106 Da. Furthermore, ion chromatography (IC), Fourier transform infrared (FT-IR) and nuclear magnetic resoance (NMR) further indicated that RLP was main composed of →2,4)-α-Rha(1→, →5)-α-L-Araf-(1→, α-D-Glu, →6)-β-D-Galp-(1→, β-D-Man and →4)-α-GalpA-(1→. In vivo antitumor activities of RLP were carried out by using H22 tumor-bearing mice model. The results shown that RLP (100 and 300 mg/kg) could inhibit tumor growth of H22 cells from 23.59 % to 45.52 % and protect thymuses and spleen without damage. In addition, according to cell cycle, AV-FITC/PI and JC-1, RLP could induce dose-dependent apoptosis of H22 cells via S phase arrested which was through a mitochondrial related pathway. Our data indicated that RLP has a broader application prospect in anti-tumor preparations. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2213-4530 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2213453022001689; https://doaj.org/toc/2213-4530 |
| DOI: |
10.1016/j.fshw.2022.07.056 |
| URL الوصول: |
https://doaj.org/article/482678fb486048adb941bdc6abfea807 |
| رقم الانضمام: |
edsdoj.482678fb486048adb941bdc6abfea807 |
| قاعدة البيانات: |
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