التفاصيل البيبلوغرافية
| العنوان: |
Drug persistence and need for dose intensification to adalimumab therapy; the importance of therapeutic drug monitoring in inflammatory bowel diseases |
| المؤلفون: |
Lorant Gonczi, Zsuzsanna Kurti, Mariann Rutka, Zsuzsanna Vegh, Klaudia Farkas, Barbara D. Lovasz, Petra A. Golovics, Krisztina B. Gecse, Balazs Szalay, Tamas Molnar, Peter L. Lakatos |
| المصدر: |
BMC Gastroenterology, Vol 17, Iss 1, Pp 1-7 (2017) |
| بيانات النشر: |
BMC, 2017. |
| سنة النشر: |
2017 |
| المجموعة: |
LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: |
Adalimumab, Therapeutic drug monitoring, Inflammatory bowel diseases, Loss of response, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: |
Abstract Background Therapeutic drug monitoring (TDM) aid therapeutic decision making in patients with inflammatory bowel disease (IBD) who lose response to anti-TNF therapy. Our aim was to evaluate the frequency and predictive factors of loss of response (LOR) to adalimumab using TDM in IBD patients. Methods One hundred twelve IBD patients (with 214 TDM measurements, CD/UC 84/28, male/female 50/62, mean age CD/UC: 36/35 years) were enrolled in this consecutive cohort from two referral centres in Hungary. Demographic data were comprehensively collected and harmonized monitoring strategy was applied. Previous and current therapy, laboratory data and clinical activity were recorded at the time of TDM. Patients were evaluated either at the time of suspected LOR or during follow-up. TDM measurements were determined by commercial ELISA (LISA TRACKER, Theradiag, France). Results Among 112 IBD patients, LOR/drug persistence was 25.9%/74.1%. The cumulative ADA positivity (>10 ng/mL) and low TL ( |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-230X |
| Relation: |
http://link.springer.com/article/10.1186/s12876-017-0654-1; https://doaj.org/toc/1471-230X |
| DOI: |
10.1186/s12876-017-0654-1 |
| URL الوصول: |
https://doaj.org/article/48030799dcbf4f5f9cdd163826762379 |
| رقم الانضمام: |
edsdoj.48030799dcbf4f5f9cdd163826762379 |
| قاعدة البيانات: |
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