Academic Journal
Clinical characterization of colitis arising from anti-PD-1 based therapy
| العنوان: | Clinical characterization of colitis arising from anti-PD-1 based therapy |
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| المؤلفون: | Daniel Y Wang, Meghan J Mooradian, DaeWon Kim, Neil J Shah, Sarah E Fenton, Robert M Conry, Rutika Mehta, Ann W. Silk, Alice Zhou, Margaret L Compton, Rami N Al-Rohil, Sunyoung Lee, Amber L Voorhees, Lisa Ha, Svetlana McKee, Jacqueline T Norrell, Janice Mehnert, Igor Puzanov, Jeffrey A Sosman, Sunandana Chandra, Geoffrey T Gibney, Suthee Rapisuwon, Zeynep Eroglu, Ryan Sullivan, Douglas B Johnson |
| المصدر: | OncoImmunology, Vol 8, Iss 1 (2019) |
| بيانات النشر: | Taylor & Francis Group, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Immunologic diseases. Allergy LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | colitis, immune-related adverse events, anti-programmed-death-1, immunotherapy, melanoma, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Colitis is a frequent, clinically-significant immune-related adverse event caused by anti-programmed death-1 (PD-1). The clinical features, timing, and management of colitis with anti-PD-1-based regimens are not well-characterized. Patients with advanced melanoma that received either anti-PD-1 monotherapy (“monotherapy”) or combined with ipilimumab (“combination therapy”) were screened from 8 academic medical centers, to identify those with clinically-relevant colitis (colitis requiring systemic steroids). Of 1261 patients who received anti-PD-1-based therapy, 109 experienced colitis. The incidence was 3.2% (30/937) and 24.4% (79/324) in the monotherapy and combination therapy cohorts, respectively. Patients with colitis from combination therapy had significantly earlier symptom onset (7.2 weeks vs 25.4 weeks, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2162-402X 2162402X |
| Relation: | https://doaj.org/toc/2162-402X |
| DOI: | 10.1080/2162402X.2018.1524695 |
| URL الوصول: | https://doaj.org/article/47c6c7c86d354dbcaa13aa6907596ec4 |
| رقم الانضمام: | edsdoj.47c6c7c86d354dbcaa13aa6907596ec4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2162402X |
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| DOI: | 10.1080/2162402X.2018.1524695 |