Academic Journal
Synthesis and pharmacological evaluation of several N-(2-nitrophenyl) piperazine derivatives
| العنوان: | Synthesis and pharmacological evaluation of several N-(2-nitrophenyl) piperazine derivatives |
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| المؤلفون: | Andrić Deana, Tovilović Gordana, Roglić Goran, Vasković Đurđica, Šoškić Vukić, Tomić Mirko, Kostić-Rajačić Slađana |
| المصدر: | Journal of the Serbian Chemical Society, Vol 72, Iss 5, Pp 429-435 (2007) |
| بيانات النشر: | Serbian Chemical Society, 2007. |
| سنة النشر: | 2007 |
| المجموعة: | LCC:Chemistry |
| مصطلحات موضوعية: | arylpiperazines, benzimidazoles, dopamine receptors, serotonin receptors, atypical antipsychotic, Chemistry, QD1-999 |
| الوصف: | Six newly synthesized heterocyclic (2-nitrophenyl)piperazines, with a specific structure of the heteroaryl group, whichmimics the catechol moiety of dopamine (benzimidazoles and substituted benzimidazoles), were evaluated for their binding affinity to rat dopamine (DA), serotonin (5-HT) and _1 receptors. All compounds with a benzimidazole group had a 5-HT2A/D2 receptors binding ratio characteristic for atypical neuroleptics (>1, pK i values). Compound 7c, 4-bromo-6-{2-_4-(2-nitrophenyl)piperazin- 1-yl_ethyl}-1H-benzimidazole, expressed higher affinities for all receptor classes than clozapine. Also, it exhibited the best characteristic for atypical neuroleptics and presents a compound with the best profile for further in vivo investigations. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0352-5139 1820-7421 |
| Relation: | https://doaj.org/toc/0352-5139; https://doaj.org/toc/1820-7421 |
| DOI: | 10.2298/JSC0705429A |
| URL الوصول: | https://doaj.org/article/47781f5cb1054ae19dc85e9d0523f79d |
| رقم الانضمام: | edsdoj.47781f5cb1054ae19dc85e9d0523f79d |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 03525139 18207421 |
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| DOI: | 10.2298/JSC0705429A |