التفاصيل البيبلوغرافية
| العنوان: |
Oncolytic viruses alter the biogenesis of tumor extracellular vesicles and influence their immunogenicity |
| المؤلفون: |
Ugo Hirigoyen, Coraly Guilbaud, Morgane Krejbich, Morgane Fouet, Judith Fresquet, Bastien Arnaud, Emmanuelle Com, Charles Pineau, Gwenann Cadiou, Julien Burlaud-Gaillard, Philippe Erbs, Delphine Fradin, Nathalie Labarrière, Jean-François Fonteneau, Tacien Petithomme, Nicolas Boisgerault |
| المصدر: |
Molecular Therapy: Oncology, Vol 32, Iss 4, Pp 200887- (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
MT: Regular Issue, oncolytic viruses, extracellular vesicles, vesicular stomatitis virus, vaccinia virus, t cell, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Extracellular vesicles (EVs) are mediators of intercellular communication in the tumor microenvironment. Tumor EVs are commonly associated with metastasis, immunosuppression or drug resistance. Viral infections usually increase EV secretion, but little is known about the effect of oncolytic viruses (OVs) on tumor EVs. Here, we investigated the impact of oncolytic vesicular stomatitis virus (VSV) and vaccinia virus on EVs secreted by human melanoma and thoracic cancer cells. We found that OV infection increases the production of EVs by tumor cells. These EVs contain proteins of viral origin, such as VSV-G, thus creating a continuum of particles sharing markers of both canonical EVs and viruses. As such, the presence of VSV-G on EVs improves the transfer of their protein content to cell types commonly found in the tumor microenvironment. A proteomic analysis also revealed that EVs-OV secreted during VSV infection are enriched in immunity-related proteins. Finally, CD8+ T cells incubated with EVs-OV from infected cells display slightly enhanced cytotoxic functions. Taken together, these data suggest that OVs enhance the communication mediated by tumor EVs, which could participate in the therapeutic efficacy of OVs. These results also provide rationale for engineering OVs to exploit EVs and disseminate therapeutic proteins within the tumor microenvironment. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2950-3299 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2950329924001292; https://doaj.org/toc/2950-3299 |
| DOI: |
10.1016/j.omton.2024.200887 |
| URL الوصول: |
https://doaj.org/article/476ae58ab35d439fa36d12f1b6f5d08e |
| رقم الانضمام: |
edsdoj.476ae58ab35d439fa36d12f1b6f5d08e |
| قاعدة البيانات: |
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