التفاصيل البيبلوغرافية
| العنوان: |
Assessment of Donor Derived Cell Free DNA (dd-cfDNA) at Surveillance and at Clinical Suspicion of Acute Rejection in Renal Transplantation |
| المؤلفون: |
Evangelos Mantios, Vassilis Filiopoulos, Pantelis Constantoulakis, George Liapis, Angeliki Vittoraki, Silvia Casas, Smaragdi Marinaki, John N Boletis |
| المصدر: |
Transplant International, Vol 36 (2023) |
| بيانات النشر: |
Frontiers Media S.A., 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Specialties of internal medicine |
| مصطلحات موضوعية: |
dd-cfDNA, kidney allograft, transplantation, rejection, biomarker, Specialties of internal medicine, RC581-951 |
| الوصف: |
In our prospective, unicenter cohort study, we collected blood samples from 30 newly kidney transplanted patients, at month 1, 2, 3, and 5 for dd-cfDNA analysis, along with creatinine/eGFR and DSA monitoring, and from 32 patients who underwent an indication biopsy and whose dd-cfDNA levels were measured at the time of biopsy and 1 month afterwards. Fourteen of 32 (43.8%) patients in the biopsy group were diagnosed with TCMR and 5 of 32 (15.6%) with ABMR. Dd-cfDNA proved to be better than creatinine in diagnosing rejection from non-rejection in patients who were biopsied. When a dd-cfDNA threshold of 0.5% was chosen, sensitivity was 73.7% and specificity was 92.3% (AUC: 0.804, 0.646–0.961). In rejection patients, levels of dd-cfDNA prior to biopsy (0.94%, 0.3–2.0) decreased substantially after initiation of treatment with median returning to baseline already at 1 month (0.33%, 0.21–0.51, p = 0.0036). In the surveillance group, high levels of dd-cfDNA (>0.5%) from second month post-transplantation were correlated with non-increasing eGFR 1 year post-transplantation. The study used AlloSeq kit for kidney transplant surveillance for first time and confirmed dd-cfDNA’s ability to detect rejection and monitor treatment, as well as to predict worse long-term outcomes regarding eGFR. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1432-2277 |
| Relation: |
https://www.frontierspartnerships.org/articles/10.3389/ti.2023.11507/full; https://doaj.org/toc/1432-2277 |
| DOI: |
10.3389/ti.2023.11507 |
| URL الوصول: |
https://doaj.org/article/ece47506b29b44939e1c3d6e771034bd |
| رقم الانضمام: |
edsdoj.47506b29b44939e1c3d6e771034bd |
| قاعدة البيانات: |
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