التفاصيل البيبلوغرافية
| العنوان: |
RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors |
| المؤلفون: |
Pratiksha I. Thakore, Jennifer B. Kwon, Christopher E. Nelson, Douglas C. Rouse, Matthew P. Gemberling, Matthew L. Oliver, Charles A. Gersbach |
| المصدر: |
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018) |
| بيانات النشر: |
Nature Portfolio, 2018. |
| سنة النشر: |
2018 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Science |
| الوصف: |
Repression of gene transcription using CRISPR-Cas9 has been achieved in vitro but not for delivery into adult animal models. Here, the authors use AAV8 to deliver the transcriptional repressor dSaCas9KRAB to the cholesterol regulator Pcsk9, and show repression up to 24 weeks and reduced cholesterol levels in mice. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-018-04048-4 |
| URL الوصول: |
https://doaj.org/article/46f1559feeb54a51902bab3a11b455bc |
| رقم الانضمام: |
edsdoj.46f1559feeb54a51902bab3a11b455bc |
| قاعدة البيانات: |
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