Association of Ulcerative Colitis with FUT2 and FUT3 Polymorphisms in Patients from Southeast China.

التفاصيل البيبلوغرافية
العنوان:	Association of Ulcerative Colitis with FUT2 and FUT3 Polymorphisms in Patients from Southeast China.
المؤلفون:	Dingyuan Hu, Daguan Zhang, Shuzi Zheng, Maodong Guo, Xinxin Lin, Yi Jiang
المصدر:	PLoS ONE, Vol 11, Iss 1, p e0146557 (2016)
بيانات النشر:	Public Library of Science (PLoS), 2016.
سنة النشر:	2016
المجموعة:	LCC:Medicine LCC:Science
مصطلحات موضوعية:	Medicine, Science
الوصف:	Dysbiosis of intestinal microbiota has been implicated in ulcerative colitis (UC). Fucosyltransferase (FUT) 2 and FUT3 determine expression of histo-blood group antigens in the gut and may affect the intestinal microbiota. We investigated the association between FUT2 and FUT3 polymorphisms and UC in Chinese patients.We genotyped FUT2 (rs281377, rs1047781 and rs601338) and FUT3 (rs28362459, rs3745635 and rs3894326) in 485 UC patients and 580 healthy controls using SNaPshot. We also evaluated expression of Lewis a and b antigens in the sigmoid colon of 7 UC patients and 7 patients with benign colonic polyps.The frequencies of mutant allele (A) and genotype (GA+AA) in FUT3 (rs3745635) were higher in UC patients than controls (P = 0.016, 95%CI: 1.339-1.699; P = 0.038, 95%CI: 1.330-1.742, respectively). Stratified analyses revealed that the frequencies of mutant allele (G) and genotype (TG+GG) of FUT3 (rs28362459) were significantly lower in patients with extensive colitis than those with distal colitis (P
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	1932-6203
Relation:	http://europepmc.org/articles/PMC4713070?pdf=render; https://doaj.org/toc/1932-6203
DOI:	10.1371/journal.pone.0146557
URL الوصول:	https://doaj.org/article/46971364df084e8bb08993b92e4ea8b9
رقم الانضمام:	edsdoj.46971364df084e8bb08993b92e4ea8b9
قاعدة البيانات:	Directory of Open Access Journals

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الوصف
تدمد:	19326203
DOI:	10.1371/journal.pone.0146557