التفاصيل البيبلوغرافية
| العنوان: |
A metagenome-wide association study of HIV disease progression in HIV controllers |
| المؤلفون: |
Luis Miguel Real, María E. Sáez, Anais Corma-Gómez, Antonio Gonzalez-Pérez, Christian Thorball, Rocío Ruiz, María Reyes Jimenez-Leon, Alejandro Gonzalez-Serna, Carmen Gasca-Capote, María José Bravo, José Luis Royo, Alberto Perez-Gomez, María Inés Camacho-Sojo, Isabel Gallego, Joana Vitalle, Sara Bachiller, Alicia Gutierrez-Valencia, Francisco Vidal, Jacques Fellay, Mathias Lichterfeld, Ezequiel Ruiz-Mateos |
| المصدر: |
iScience, Vol 26, Iss 7, Pp 107214- (2023) |
| بيانات النشر: |
Elsevier, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Health sciences, Medicine, Natural sciences, Biological sciences, Immunology, Science |
| الوصف: |
Summary: Some HIV controllers experience immunologic progression with CD4+ T cell decline. We aimed to identify genetic factors associated with CD4+ T cell lost in HIV controllers. A total of 561 HIV controllers were included, 442 and 119 from the International HIV controllers Study Cohort and the Swiss HIV Cohort Study, respectively. No SNP or gene was associated with the long-term non-progressor HIV spontaneous control phenotype in the individual GWAS or in the meta-analysis. However, SNPs previously associated with natural HIV control linked to HLA-B (rs2395029 [p = 0.005; OR = 1.70], rs59440261 [p = 0.003; OR = 1.78]), MICA (rs112243036 [p = 0.011; OR = 1.45]), and PSORS1C1 loci (rs3815087 [p = 0.017; OR = 1.39]) showed nominal association with this phenotype. Genetic factors associated with the long-term HIV controllers without risk of immunologic progression are those previously related to the overall HIV controller phenotype. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2589-0042 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2589004223012919; https://doaj.org/toc/2589-0042 |
| DOI: |
10.1016/j.isci.2023.107214 |
| URL الوصول: |
https://doaj.org/article/c4602fb331a141b3940c26536d0eed82 |
| رقم الانضمام: |
edsdoj.4602fb331a141b3940c26536d0eed82 |
| قاعدة البيانات: |
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