التفاصيل البيبلوغرافية
| العنوان: |
Response mechanisms of resistance in L-form bacteria to different target antibiotics: Implications from oxidative stress to metabolism |
| المؤلفون: |
Yuye Zheng, Yiwei Cai, Tong Sun, Guiying Li, Taicheng An |
| المصدر: |
Environment International, Vol 187, Iss , Pp 108729- (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Environmental sciences |
| مصطلحات موضوعية: |
Antibiotic resistance, L-form bacteria, Response mechanisms, Cell wall deficient, Gram-negative bacteria, Gram-positive bacteria, Environmental sciences, GE1-350 |
| الوصف: |
Due to the specific action on bacterial cell wall, β-lactam antibiotics have gained widespread usage as they exhibit a high degree of specificity in targeting bacteria, but causing minimal toxicity to host cells. Under antibiotic pressure, bacteria may opt to shed their cell walls and transform into L-form state as a means to evade the antibiotic effects. In this study, we explored and identified diverse optimal conditions for both Gram-negative bacteria (E. coli DH5α (CTX)) and Gram-positive bacteria (B. subtilis ATCC6633), which were induced to L-form bacteria using lysozyme (0.5 ppm) and meropenem (64 ppm). Notably, when bacteria transformed into L-form state, both bacterial strains showed varying degrees of increased resistance to antibiotics polymyxin E, meropenem, rifampicin, and tetracycline. E. coli DH5α (CTX) exhibited the most significant enhancement in resistance to tetracycline, with a 128-fold increase, while B. subtilis ATCC6633 showed a 32-fold increase in resistance to tetracycline and polymyxin E. Furthermore, L-form bacteria maintained their normal metabolic activity, combined with enhanced oxidative stress, served as an adaptive strategy promoting the sustained survival of L-form bacteria. This study provided a theoretical basis for comprehending antibiotic resistance mechanisms, developing innovative treatment strategies, and confronting global antibiotic resistance challenges. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
0160-4120 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S0160412024003155; https://doaj.org/toc/0160-4120 |
| DOI: |
10.1016/j.envint.2024.108729 |
| URL الوصول: |
https://doaj.org/article/a45a7aa0d0704a72869f12f69518996b |
| رقم الانضمام: |
edsdoj.45a7aa0d0704a72869f12f69518996b |
| قاعدة البيانات: |
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