Academic Journal
The usefulness of C-reactive protein in predicting malaria parasitemia in a sub-Saharan African region.
| العنوان: | The usefulness of C-reactive protein in predicting malaria parasitemia in a sub-Saharan African region. |
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| المؤلفون: | Bismark Osei Sarfo, Andreas Hahn, Norbert Georg Schwarz, Anna Jaeger, Nimako Sarpong, Florian Marks, Yaw Adu-Sarkodie, Thalea Tamminga, Juergen May |
| المصدر: | PLoS ONE, Vol 13, Iss 8, p e0201693 (2018) |
| بيانات النشر: | Public Library of Science (PLoS), 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | BACKGROUND:Malaria remains a leading cause of childhood mortality in sub-Saharan Africa. Identifying patients who are at risk for severe manifestations at presentation still remains challenging. This study examines whether a semi-quantitative test on C-Reactive Protein (CRP) could be useful for rapidly predicting the presence or absence of malarial parasitemia in febrile children. METHOD:Data were collected from children with fever or a history of fever at the Agogo Presbyterian Hospital in the Ashanti Region of Ghana. Haematological measurements, microscopic detection of plasmodium species and semi-quantitative CRP measurements with a membrane-based immunoassay for whole blood were performed. CRP was classified as positive when the measured level was ≥ 10 mg/l. RESULTS:During 548 visits, thick blood film results could be obtained from 541 patients, 270 (49.3%) yielded parasitemia with Plasmodium spp. Whereas malaria parasites were detected in only a few patients (7.1%) with normal CRP levels (< 10mg/l), more than a half of patients with an increased CRP concentration (≥ 10 mg/l) were parasite positive (OR 14.5 [CI 4.4-47.6], p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC6078295?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0201693 |
| URL الوصول: | https://doaj.org/article/456870bc3dcc4886a11a023b9066b882 |
| رقم الانضمام: | edsdoj.456870bc3dcc4886a11a023b9066b882 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0201693 |