التفاصيل البيبلوغرافية
| العنوان: |
Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex |
| المؤلفون: |
David R. Calabrese, Xiang Chen, Elena C. Leon, Snehal M. Gaikwad, Zaw Phyo, William M. Hewitt, Stephanie Alden, Thomas A. Hilimire, Fahu He, Aleksandra M. Michalowski, John K. Simmons, Lindsey B. Saunders, Shuling Zhang, Daniel Connors, Kylie J. Walters, Beverly A. Mock, John S. Schneekloth |
| المصدر: |
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
| بيانات النشر: |
Nature Portfolio, 2018. |
| سنة النشر: |
2018 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Science |
| الوصف: |
Targeting noncoding nucleic acids with small molecules represents an important and significant challenge in chemical biology and drug discovery. Here the authors characterize DC-34, a small molecule that exhibits selective binding to specific G4 structures, and provide a structural basis for its selectivity |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-018-06315-w |
| URL الوصول: |
https://doaj.org/article/d45674f52573447395e321fc6dc2bc80 |
| رقم الانضمام: |
edsdoj.45674f52573447395e321fc6dc2bc80 |
| قاعدة البيانات: |
Directory of Open Access Journals |
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