Academic Journal
Molecular characterization and antimicrobial resistance of group A streptococcus isolates in streptococcal toxic shock syndrome cases in Japan from 2013 to 2018
| العنوان: | Molecular characterization and antimicrobial resistance of group A streptococcus isolates in streptococcal toxic shock syndrome cases in Japan from 2013 to 2018 |
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| المؤلفون: | Tadayoshi Ikebe, Rumi Okuno, Yoshiko Kanda, Mari Sasaki, Takahiro Yamaguchi, Hitoshi Otsuka, Yu Kazawa, Miyuki Suzuki, Hitomi Ohya, Kaoru Uchida, Makoto Ohnishi |
| المصدر: | International Journal of Medical Microbiology, Vol 311, Iss 3, Pp 151496- (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Microbiology LCC:Other systems of medicine |
| مصطلحات موضوعية: | Group A streptococcus, Streptococcal toxic shock syndrome, emm type, Antibiotic resistance, Microbiology, QR1-502, Other systems of medicine, RZ201-999 |
| الوصف: | Streptococcal toxic shock syndrome (STSS) is a severe invasive infection characterized by the sudden onset of shock, multi-organ failure, and puerperal sepsis and shows high mortality. Its primary cause is group A streptococcus (GAS, Streptococcus pyogenes). In this study, we genotyped the cell-surface M virulence protein gene (emm) from 621 GAS isolates obtained from patients with STSS in Japan in 2013–2018 and performed antimicrobial susceptibility testing using the broth microdilution method. The predominant emm type was found to be 1, followed by 89, 12, and 3, which were identified in more than 70 % of STSS isolates. The proportions of emm3 and emm89 increased from 2.4 % and 12.0 %, respectively, during 2010–2012 to 5.6 % and 23.3 % during 2013–2018. In contrast, the proportion of emm1 decreased from 60.6 % to 39.3 % during the same two periods. Some emm types showed increasing proportions and were not isolated from patients with STSS in 2010–2012. Among these, an emm76 type increased in prevalence and was not included in the 30-valent M protein-based vaccine. Continual investigation of changes in the epidemiology of GAS which causes STSS can provide useful monitoring information such as future vaccination strategies and the emergence status of antimicrobial-resistant bacteria. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1438-4221 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1438422121000254; https://doaj.org/toc/1438-4221 |
| DOI: | 10.1016/j.ijmm.2021.151496 |
| URL الوصول: | https://doaj.org/article/455a066c3b8647ef963c8d49ffdf8bed |
| رقم الانضمام: | edsdoj.455a066c3b8647ef963c8d49ffdf8bed |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14384221 |
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| DOI: | 10.1016/j.ijmm.2021.151496 |