التفاصيل البيبلوغرافية
| العنوان: |
Laparoscopic-based perivascular renal sympathetic nerve denervation: a feasibility study in a porcine model |
| المؤلفون: |
Linwei Zhao, Enyong Su, Xiaohang Yang, Binbin Zhu, Zhiqiang Fan, Xianpei Wang, Datun Qi, Lijie Zhu, Mingfu Bai, You Zhang, Qiuping Zhao, Muwei Li, Chuanyu Gao |
| المصدر: |
European Journal of Medical Research, Vol 25, Iss 1, Pp 1-11 (2020) |
| بيانات النشر: |
BMC, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Medicine |
| مصطلحات موضوعية: |
Laparoscope, Renal sympathetic nerve denervation, Hypertension, Medicine |
| الوصف: |
Abstract Background This study aims to evaluate the effects and safety of laparoscopic-based perivascular renal sympathetic nerve denervation (RDN) in a porcine model fed a high-fat diet. Method Thirty-six high-fat diet-fed Bama minipigs were randomly divided into an RDN group (n = 18), in which minipigs received laparoscopic-based perivascular RDN, and a sham group (n = 18). All pigs were fed the high-fat diet after the operation to establish a model of obesity-induced hypertension. Bama pigs in the RDN and sham groups were killed at 3 time points [2 days after RDN (n = 6), day 90 (n = 6) and day 180 (n = 6)]. Result The systolic blood pressure (SBP) and noradrenaline (NE) concentration in the kidney tissue were significantly lower in the RDN group than in the sham group at 2 days (113.83 ± 3.26 mmHg vs 129.67 ± 3.32 mmHg, P = 0.011, and 112.02 ± 17.34 ng/g vs 268.48 ± 20.61 ng/g, P |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2047-783X |
| Relation: |
http://link.springer.com/article/10.1186/s40001-020-00422-5; https://doaj.org/toc/2047-783X |
| DOI: |
10.1186/s40001-020-00422-5 |
| URL الوصول: |
https://doaj.org/article/44c2c05c432f4e269395c6d892e998f4 |
| رقم الانضمام: |
edsdoj.44c2c05c432f4e269395c6d892e998f4 |
| قاعدة البيانات: |
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