Academic Journal
A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans.
| العنوان: | A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans. |
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| المؤلفون: | Elizabeth K Marsh, Maaike C W van den Berg, Robin C May |
| المصدر: | PLoS ONE, Vol 6, Iss 3, p e16839 (2011) |
| بيانات النشر: | Public Library of Science (PLoS), 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Lysozymes are antimicrobial enzymes that perform a critical role in resisting infection in a wide-range of eukaryotes. However, using the nematode Caenorhabditis elegans as a model host we now demonstrate that deletion of the protist type lysozyme LYS-7 renders animals susceptible to killing by the fatal fungal human pathogen Cryptococcus neoformans, but, remarkably, enhances tolerance to the enteric bacteria Salmonella Typhimurium. This trade-off in immunological susceptibility in C. elegans is further mediated by the reciprocal activity of lys-7 and the tyrosine kinase abl-1. Together this implies a greater complexity in C. elegans innate immune function than previously thought. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC3047536?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0016839 |
| URL الوصول: | https://doaj.org/article/44b1704941d7456db332fe3e24a52e62 |
| رقم الانضمام: | edsdoj.44b1704941d7456db332fe3e24a52e62 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0016839 |