التفاصيل البيبلوغرافية
| العنوان: |
Long non-coding RNAs in cancer stem cells |
| المؤلفون: |
Melanie Schwerdtfeger, Vincenzo Desiderio, Sebastian Kobold, Tarik Regad, Silvia Zappavigna, Michele Caraglia |
| المصدر: |
Translational Oncology, Vol 14, Iss 8, Pp 101134- (2021) |
| بيانات النشر: |
Elsevier, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
In recent years, it has been evidenced that the human transcriptome includes several types of non-coding RNAs (ncRNAs) that are mainly involved in the regulation of different cellular processes. Among ncRNAs, long-non-coding RNAs (lncRNAs) are defined as longer than 200 nucleotides and have been shown to be involved in several physiological and pathological events, including immune system regulation and cancer. Cancer stem cells (CSCs) are defined as a population of cancer cells that possess characteristics, such as resistance to standard treatments, cancer initiation, ability to undergo epithelial-to-mesenchymal transition, and the ability to invade, spread, and generate metastases. The cancer microenvironment, together with genetic and epigenetic factors, is fundamental for CSC maintenance and tumor growth and progression. Unsurprisingly, lncRNAs have been involved in both CSC biology and cancer progression, prognosis and recurrence. Here we review the most recent literature on IncRNAs involvement in CSC biology and function. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1936-5233 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1936523321001261; https://doaj.org/toc/1936-5233 |
| DOI: |
10.1016/j.tranon.2021.101134 |
| URL الوصول: |
https://doaj.org/article/449460f7c38c4d83a1d2651bb834f813 |
| رقم الانضمام: |
edsdoj.449460f7c38c4d83a1d2651bb834f813 |
| قاعدة البيانات: |
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