Academic Journal
Plasma levels of leptin and visfatin in rheumatoid arthritis patients; is there any relationship with joint damage?
| العنوان: | Plasma levels of leptin and visfatin in rheumatoid arthritis patients; is there any relationship with joint damage? |
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| المؤلفون: | Zahra Mirfeizi, Zohreh Noubakht, Ali Etemad Rezaie, Mohammad Hassan Jokar, Zhaleh Shariati Sarabi |
| المصدر: | Iranian Journal of Basic Medical Sciences, Vol 17, Iss 9, Pp 662-666 (2014) |
| بيانات النشر: | Mashhad University of Medical Sciences, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Adipocytokine, rheumatoid arthritis, Leptin, Larsen score, Visfatin, Medicine |
| الوصف: | Objective (s):Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder, primarily targeting the synovium and articular cartilage that leads to joint damage. Recent reports have suggested the role of adipocytokines in mediating joint damage; however it still is a matter of debate. The purpose of this study was to evaluate the association between serum values of adiopocytokines (leptin, visfatin) and radiographic joint damage in patients with RA. Materials and Methods:Fifty-four patients diagnosed with RA, based on Revised ACR Criteria 2010, with 1-5 year disease duration since diagnosis, were enrolled. Twenty-nine of patients had erosion in radiographic studies and 25patients had no erosion. Radiographic joint damages were defined according to Larsen Score. Additionally, serum levels of adipocytokines were measured and cross-sectional associations with radiographic damage were explored, adjusting for pertinent confounders. Results:The serum level of visfatin were significantly higher in patients with radiographic joint damage compared with patients with no joint damage (P=0.013). This difference remained significant after adjustment for C-reactive protein levels (P=0.008), but not after adjustment for disease duration (P=0.247). The mean leptin serum levels were not different between these two groups (P=0.903). There was a positive correlation between leptin levels and BMI (r=0.494, P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-3866 2008-3874 |
| Relation: | http://ijbms.mums.ac.ir/pdf_3328_accc73eff9324bd30fa9ccdc8ac7a991.html; https://doaj.org/toc/2008-3866; https://doaj.org/toc/2008-3874 |
| URL الوصول: | https://doaj.org/article/e4454d498d694817ab005fb56e0fad59 |
| رقم الانضمام: | edsdoj.4454d498d694817ab005fb56e0fad59 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20083866 20083874 |
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