التفاصيل البيبلوغرافية
| العنوان: |
Impact of age and induction therapy on outcome of 180 adult patients with acute myeloid leukemia; retrospective analysis and literature review |
| المؤلفون: |
Khadega A. Abuelgasim, Bandar Albuhayri, Rayan Munshi, Areej Al Mugairi, Bader Alahmari, Giamal Gmati, Hind Salama, Mohsen Alzahrani, Ayman Alhejazi, Ahmed Alaskar, Moussab Damlaj |
| المصدر: |
Leukemia Research Reports, Vol 14, Iss , Pp 100206- (2020) |
| بيانات النشر: |
Elsevier, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
Acute myeloid leukemia, High-risk cytogenetics, Standard induction, Elderly, Allogeneic hematopoietic stem cell transplantation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
The prognosis of acute myeloid leukemia (AML) remains poor. Among 180 patients, the median age was 53 (14-88) years. The overall 2-year disease free survival (DFS) was 28.6% (+/- 3.4), 47.7% (+/- 6.6%) for ≤ 40, 23.6% (+/- 5.8%) for 41–60 and 11.7% (+/- 4.2%) for ≥61 (p< 0.0001). The overall 2-year survival (OS) was 45.3% (+/- 3.8%), 78.6% (+/- 5.5%) for ≤40, 43.5% (+/- 6.9%) for 41–60 and 15.8% (+/- 4.8%) for ≥61 (p< 0.0001). Induction outcome of ≥61 was best in high dose chemotherapy (HDC) group (p < 0.0001). Only those ≤40 had durable DFS and OS. HDC appears to improve the outcome of older AML patients. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2213-0489 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2213048920300121; https://doaj.org/toc/2213-0489 |
| DOI: |
10.1016/j.lrr.2020.100206 |
| URL الوصول: |
https://doaj.org/article/44019adc9475490ebc3f071cb2cdbec1 |
| رقم الانضمام: |
edsdoj.44019adc9475490ebc3f071cb2cdbec1 |
| قاعدة البيانات: |
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