التفاصيل البيبلوغرافية
| العنوان: |
Association of LAG3 genetic variation with an increased risk of PD in Chinese female population |
| المؤلفون: |
Wenyuan Guo, Miaomiao Zhou, Jiewen Qiu, Yuwan Lin, Xiang Chen, Shuxuan Huang, Mingshu Mo, Hanqun Liu, Guoyou Peng, Xiaoqin Zhu, Pingyi Xu |
| المصدر: |
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-8 (2019) |
| بيانات النشر: |
BMC, 2019. |
| سنة النشر: |
2019 |
| المجموعة: |
LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: |
LAG3, Parkinson disease, α-Synuclein, Transmission, Biomarker, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: |
Abstract Background Emerging evidence suggests that α-synuclein (α-syn) aggregation and intercellular transmission contributes to pathogenesis of Parkinson’s disease (PD) and the toxic fibrillary α-syn binds lymphocyte-activation gene 3 (LAG3) receptor that mediates α-syn transmission. The deletion of LAG3 in animal models was shown to limit α-syn spreading and alleviate the pathological changes of dopaminergic neurons and animal behavioral deficits induced by α-syn aggregation. However, little is known about the genetic association of LAG3 variation with human PD development. Objective Here we investigated LAG3 single nucleotide polymorphisms (SNPs) and examined the levels of soluble LAG3 (sLAG3) of CSF and serum from Chinese PD patients. Methods We enrolled 646 PD patients and 536 healthy controls to conduct a case-control study. All the participants were genotyped using Sequenom iPLEX Assay and the partial cerebrospinal fluid (CSF) and serum samples were assessed by Meso Scale Discovery electrochemiluminescence (MSD-ECL) immunoassay to measure sLAG3 concentration. Results As a result, distributions of rs1922452-AA (1.975, 95% confidence interval (CI) 1.311–2.888, p = 0.001) and rs951818-CC (OR = 2.03, 95% CI 1.369–3.010, p = 0.001) genotype frequencies were found higher in the female PD patients than controls, respectively, and a strong linkage disequilibrium (LD) was calculated on the variants. The level of sLAG3 in CSF of PD patients was found to significantly differ from that of controls (51.56 ± 15.05 pg/ml vs 88.49 ± 62.96 pg/ml, p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1742-2094 |
| Relation: |
https://doaj.org/toc/1742-2094 |
| DOI: |
10.1186/s12974-019-1654-6 |
| URL الوصول: |
https://doaj.org/article/a438c6053dc348518c118f987b2e6f93 |
| رقم الانضمام: |
edsdoj.438c6053dc348518c118f987b2e6f93 |
| قاعدة البيانات: |
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