MYSM1 induces apoptosis and sensitizes TNBC cells to cisplatin via RSK3–phospho-BAD pathway

التفاصيل البيبلوغرافية
العنوان:	MYSM1 induces apoptosis and sensitizes TNBC cells to cisplatin via RSK3–phospho-BAD pathway
المؤلفون:	Xiaolin Guan, Xin Meng, Keyu Zhu, Jinyan Kai, Yixuan Liu, Qian Ma, Ying Tong, Hui Zheng, Suhong Xie, Xiaolu Ma, Yanchun Wang, Renquan Lu, Lin Guo
المصدر:	Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
بيانات النشر:	Nature Publishing Group, 2022.
سنة النشر:	2022
المجموعة:	LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Cytology
مصطلحات موضوعية:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671
الوصف:	Abstract Breast cancer is one of the leading causes of mortality among women. Triple-negative breast cancer (TNBC) is responsible for a large percentage of all breast cancer deaths in women. This study demonstrated the function of Myb-like, SWIRM, and MPN domains 1 (MYSM1), an H2A deubiquitinase (DUB), in TNBC. MYSM1 expression was drastically decreased in breast cancer, especially in TNBC, suggesting a potential anticancer effect. Overexpressing and suppressing MYSM1 expression in TNBC cell lines led to significant biological changes in cell proliferation. Furthermore, MYSM1 overexpression increased cisplatin-induced apoptosis, which might be attributed to RSK3 inactivation and the subsequently decreased phosphorylation of Bcl-2 antagonist of cell death (BAD) (Ser 112). The findings suggest that MYSM1 is a potential target for regulating cell apoptosis and suppressing resistance to cisplatin in TNBC.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2058-7716
Relation:	https://doaj.org/toc/2058-7716
DOI:	10.1038/s41420-022-00881-1
URL الوصول:	https://doaj.org/article/438b94b038eb42068849b5371c1fee78
رقم الانضمام:	edsdoj.438b94b038eb42068849b5371c1fee78
قاعدة البيانات:	Directory of Open Access Journals

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الوصف
تدمد:	20587716
DOI:	10.1038/s41420-022-00881-1