التفاصيل البيبلوغرافية
| العنوان: |
Fatigue in Multiple Sclerosis Is Associated with Reduced Expression of Interleukin-10 and Worse Prospective Disease Activity |
| المؤلفون: |
Luana Gilio, Fabio Buttari, Luigi Pavone, Ennio Iezzi, Giovanni Galifi, Ettore Dolcetti, Federica Azzolini, Antonio Bruno, Angela Borrelli, Marianna Storto, Roberto Furlan, Annamaria Finardi, Tatjana Pekmezovic, Jelena Drulovic, Georgia Mandolesi, Diego Fresegna, Valentina Vanni, Diego Centonze, Mario Stampanoni Bassi |
| المصدر: |
Biomedicines, Vol 10, Iss 9, p 2058 (2022) |
| بيانات النشر: |
MDPI AG, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
relapsing-remitting multiple sclerosis (RR-MS), fatigue, inflammation, IL-10, NEDA-3, T2 lesion load, Biology (General), QH301-705.5 |
| الوصف: |
In multiple sclerosis (MS), fatigue is a frequent symptom that negatively affects quality of life. The pathogenesis of fatigue is multifactorial and inflammation may play a specific role. To explore the association between fatigue, central inflammation and disease course in MS in 106 relapsing-remitting (RR)-MS patients, clinical characteristics, including fatigue and mood, were explored at the time of diagnosis. NEDA (no evidence of disease activity)-3 status after one-year follow up was calculated. Cerebrospinal fluid (CSF) levels of a set of proinflammatory and anti-inflammatory molecules and peripheral blood markers of inflammation were also analyzed. MRI structural measures were explored in 35 patients. A significant negative correlation was found at diagnosis between fatigue measured with the Modified Fatigue Impact Scale (MFIS) and the CSF levels of interleukin (IL)-10. Conversely, no significant associations were found with peripheral markers of inflammation. Higher MFIS scores were associated with reduced probability to reach NEDA-3 status after 1-year follow up. Finally, T2 lesion load showed a positive correlation with MFIS scores and a negative correlation with CSF IL-10 levels at diagnosis. CSF inflammation, and particularly the reduced expression of the anti-inflammatory molecule IL-10, may exacerbate fatigue. Fatigue in MS may reflect subclinical CSF inflammation, predisposing to greater disease activity. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2227-9059 |
| Relation: |
https://www.mdpi.com/2227-9059/10/9/2058; https://doaj.org/toc/2227-9059 |
| DOI: |
10.3390/biomedicines10092058 |
| URL الوصول: |
https://doaj.org/article/4368af12dd0a45429e0b74433b908eef |
| رقم الانضمام: |
edsdoj.4368af12dd0a45429e0b74433b908eef |
| قاعدة البيانات: |
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