التفاصيل البيبلوغرافية
| العنوان: |
First three Escherichia coli isolates harbouring mcr-1 in Uruguay |
| المؤلفون: |
Romina Papa-Ezdra, Fabio Grill Diaz, Mariela Vieytes, Virginia García-Fulgueiras, Leticia Caiata, Pablo Ávila, María Brasesco, Inés Christophersen, Nicolás F. Cordeiro, Gabriela Algorta, Antonio Galiana, Rafael Vignoli |
| المصدر: |
Journal of Global Antimicrobial Resistance, Vol 20, Iss , Pp 187-190 (2020) |
| بيانات النشر: |
Elsevier, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Microbiology |
| مصطلحات موضوعية: |
E. coli, Colistin resistance, mcr-1, IncX4, Microbiology, QR1-502 |
| الوصف: |
Objective: This report described the first Escherichia coli (E. coli) isolates harbouring mcr-1 in Uruguay. Methods: Three E. coli isolates were obtained from blood, urine and rectal swabs from different patients in two hospitals. Extended-spectrum β-lactamases (ESBL), plasmid-encoded (pAmpC) β-lactamases, plasmid-mediated quinolone resistance (PMQR) genes, class 1 integrons, and mcr-1, mcr-2 and mcr-3 were sought and characterised in three E. coli isolates. Transfer of resistance determinants was assessed by conjugation. Clonality was analysed by multilocus sequence typing. Results: All isolates were categorised as being colistin-resistant and the mcr-1 gene was detected. Two isolates were also resistant to oxyimino cephalosporins: one on account of blaCMY-2 and the other due to blaCTX-M-15, the latter also harbouring transferable quinolone-resistance genes (aac(6′)Ib-cr and qnrB). All mcr-1 genes were transferred by conjugation to recipient strains. The mcr-1-bearing isolates belonged to sequence types ST10, ST93 and ST5442. Conclusions: ST10 is considered as a high-risk clone worldwide. This type of mcr-1-harbouring clone is a major concern for human and animal health and must be under close surveillance. This study detected the presence of mcr-1 for the first time in Uruguay, albeit in an allodemic manner, associated with different antibiotic-resistance genes and from diverse clinical contexts. Considering that colistin is often the last therapeutic option available for multidrug-resistant Gram-negative bacilli infections, it is important to maximise precautions to avoid dissemination of isolates carrying mcr-1. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2213-7165 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2213716519301821; https://doaj.org/toc/2213-7165 |
| DOI: |
10.1016/j.jgar.2019.07.016 |
| URL الوصول: |
https://doaj.org/article/427cdab0d1184f36a122fc899f8d8f77 |
| رقم الانضمام: |
edsdoj.427cdab0d1184f36a122fc899f8d8f77 |
| قاعدة البيانات: |
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