التفاصيل البيبلوغرافية
| العنوان: |
Novel Monoclonal Antibody Specific toward Amyloid-β Binds to a Unique Epitope within the N-Terminal Region |
| المؤلفون: |
Giavanna Paterno, Brenda D. Moore, Brach M. Bell, Kimberly-Marie M. Gorion, Yong Ran, Stefan Prokop, Todd E. Golde, Benoit I. Giasson |
| المصدر: |
Antibodies, Vol 13, Iss 3, p 68 (2024) |
| بيانات النشر: |
MDPI AG, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: |
Amyloid-β, Alzheimer’s disease, antibody, pathology, plaques, Immunologic diseases. Allergy, RC581-607 |
| الوصف: |
Amyloid-β (Aβ) deposition throughout the neuroaxis is a classical hallmark of several neurodegenerative diseases, most notably Alzheimer’s disease (AD). Aβ peptides of varied length and diverse structural conformations are deposited within the parenchyma and vasculature in the brains of individuals with AD. Neuropathologically, Aβ pathology can be assessed using antibodies to label and characterize their features, which in turn leads to a more extensive understanding of the pathological process. In the present study, we generated a novel monoclonal antibody, which we found to be specific for the N-terminal region of Aβ. This antibody reacted to amyloid precursor protein expressed in cultured cells and labels Aβ plaques and cerebral amyloid angiopathy in brain tissue from a mouse model of amyloidosis as well as post-mortem brain tissue from patients diagnosed with AD. This highly specific novel antibody will serve as a unique tool for future studies investigating Aβ deposition in novel mouse models and cross-sectional studies using post-mortem human tissue. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2073-4468 |
| Relation: |
https://www.mdpi.com/2073-4468/13/3/68; https://doaj.org/toc/2073-4468 |
| DOI: |
10.3390/antib13030068 |
| URL الوصول: |
https://doaj.org/article/41c965890e0940ecabd13cc3195be60c |
| رقم الانضمام: |
edsdoj.41c965890e0940ecabd13cc3195be60c |
| قاعدة البيانات: |
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