Academic Journal
Synthesis, Characterization and Anticancer Activity of Chitosan Schiff Base / PEG Blend Doped with Gold and Silver Nanoparticles in Treatment of Breast Cancer Cell Line MCF-7
| العنوان: | Synthesis, Characterization and Anticancer Activity of Chitosan Schiff Base / PEG Blend Doped with Gold and Silver Nanoparticles in Treatment of Breast Cancer Cell Line MCF-7 |
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| المؤلفون: | Maha Aldabbagh, Baker F. Abdallaha, Nibras Y. Abdulla, Ibraheem J. Ibraheem |
| المصدر: | Iraqi Journal of Pharmaceutical Sciences, Vol 33, Iss 2 (2024) |
| بيانات النشر: | College of Pharmacy University of Baghdad, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | Anticancer cell line, Chitosan, Chitosan Schiff base, PEG, Nano composite, Pharmacy and materia medica, RS1-441 |
| الوصف: | In the present study, chitosan Schiff base has been prepared from chitosan reaction with the para chloro benzaldehyde. The AuNPs and AgNPs were manufacture by extract of onion peels as a reducing agent. The AuNPs and AgNPs that have been synthesized were characterized through UV-vis spectroscopy the XRD analyses and SEM microscopy. The polymer blends of the chitosan / PEG has been prepared through using the approach of solution casting. Chitosan Schiff base / PEG Au and Ag nano-composites were synthesized nano composites and polymer blends have been characterized by FTIR which confirm the formation of Schiff base by revealing a new band of absorption at 1693 cm-1 as a result of the (C=N) imine group. FESEM, DSC and TGA confirms the thermal stability of the prepared polymer blends and nanocomposites, nano composites have shown good results in inhibiting breast cancer cell line MCF-7, IC50 of nanocomposite = 19.44 µg / mL. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1683-3597 2521-3512 |
| Relation: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/2548; https://doaj.org/toc/1683-3597; https://doaj.org/toc/2521-3512 |
| DOI: | 10.31351/vol33iss2pp101-111 |
| URL الوصول: | https://doaj.org/article/c4153c68ff6b47a39728504ec52fbf11 |
| رقم الانضمام: | edsdoj.4153c68ff6b47a39728504ec52fbf11 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 16833597 25213512 |
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| DOI: | 10.31351/vol33iss2pp101-111 |