Academic Journal
Relationship between androgen receptor and androgen receptor-related protein expression in breast cancers focusing on morphologically identified carcinoma with apocrine differentiation
| العنوان: | Relationship between androgen receptor and androgen receptor-related protein expression in breast cancers focusing on morphologically identified carcinoma with apocrine differentiation |
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| المؤلفون: | Haruto Nishida, Ami Kato, Ryo Kaimori, Kazuhiro Kawamura, Tsutomu Daa |
| المصدر: | Scientific Reports, Vol 15, Iss 1, Pp 1-9 (2025) |
| بيانات النشر: | Nature Portfolio, 2025. |
| سنة النشر: | 2025 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Breast cancer, Androgen receptor, Molecular targeted therapy, Apocrine differentiation, Medicine, Science |
| الوصف: | Abstract Breast cancer (BC) is classified based on the expression of histopathological markers, namely, estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2). Carcinomas with apocrine differentiation (CAD) are classified based on morphology. Androgen receptor (AR) is highly expressed in CAD; however, no study has comprehensively examined AR-related proteins in CAD. Therefore, we examined the expression of AR-related proteins and AR, compared protein expression patterns between morphologically identified CAD and other BC subtypes, and investigated CAD characteristics. We performed immunohistochemistry for AR and various AR-related proteins in 66 invasive ductal carcinoma (32 ER+/PgR+/HER2−, 8 ER+/PgR+/HER2+, 12 ER−/PgR−/HER2+, and 14 ER−/PgR−/HER2− [triple-negative breast cancer)), 21 invasive lobular carcinoma, and 27 CAD cases. In the CAD group, all cases were AR-positive; some AR-related proteins were highly expressed. Nuclear phosphorylated-mammalian target of rapamycin was highly expressed in CAD cases compared with that in other BC groups, with a 33.3% sensitivity and 97.7% specificity. AR-expressing CAD cases exhibited high expression of other AR-related proteins. Specifically, the combination of AR+, GCDFP15+, and ER − or AR+, FOXA1+, and ER − may be useful for the diagnosis and treatment of AR-positive BC and CAD. These results may assist in androgen-related molecular targeted therapy research. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-025-87403-y |
| URL الوصول: | https://doaj.org/article/40ee07a6f2144ef5b8e4ffa792d5ed42 |
| رقم الانضمام: | edsdoj.40ee07a6f2144ef5b8e4ffa792d5ed42 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-025-87403-y |