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Pan-cancer analysis and the oncogenic role of Glypican 1 in hepatocellular carcinoma

التفاصيل البيبلوغرافية
العنوان: Pan-cancer analysis and the oncogenic role of Glypican 1 in hepatocellular carcinoma
المؤلفون: Li Cao, Fang Li, Shuang Cai, Jinyuan Zhang, Chen Guo, Sadiq Ali, Jing Zhou, Xintao Jing, Xiaofei Wang, Yannan Qin, Fei Wu
المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
بيانات النشر: Nature Portfolio, 2024.
سنة النشر: 2024
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: GPC-1, Pan-cancer analysis, HCC, Proliferation, Apoptosis, Medicine, Science
الوصف: Abstract Recent studies indicate that Glypican 1 (GPC-1) is aberrantly expressed and plays a key role in certain cancers, but little is known in the hepatocellular carcinoma. Raw data from TCGA, GTEx and TIMER databases were utilized to comprehensively analyze GPC-1 expression landscape in pan-cancer, and the biological function of GPC-1 was investigated in liver cancer cells. The results revealed that GPC-1 is highly expressed in HCC, negatively correlated with survival, and also positively correlated with immune infiltration and clinical stage. Furthermore, GPC-1 promoted cell proliferation and inhibited apoptosis in the HCC cell lines. WGCNA analysis and HCCDB database revealed that Akt acted as a key molecule related to GPC-1, influencing biological functions and regulating cell malignant behaviors via the AKT signaling pathway. In conclusion, our findings provide a relatively comprehensive understanding of the oncogenic role of GPC-1 in HCC, implying that GPC-1 could serve as an innovative therapeutic target.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-024-66838-9
URL الوصول: https://doaj.org/article/40a0975b439a4617a3a48d808618ec89
رقم الانضمام: edsdoj.40a0975b439a4617a3a48d808618ec89
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-024-66838-9