التفاصيل البيبلوغرافية
| العنوان: |
Cobalt(III)–Macrocyclic Scaffolds with Anti-Cancer Stem Cell Activity |
| المؤلفون: |
Jiaxin Fang, Philipp Gerschel, Kuldip Singh, Ulf-Peter Apfel, Kogularamanan Suntharalingam |
| المصدر: |
Molecules, Vol 29, Iss 12, p 2743 (2024) |
| بيانات النشر: |
MDPI AG, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Organic chemistry |
| مصطلحات موضوعية: |
metallopharmaceuticals, bioinorganic chemistry, cobalt, cancer stem cells, cyclam, 14-membered macrocycles, Organic chemistry, QD241-441 |
| الوصف: |
Cobalt(III) compounds with tetradentate ligands have been widely employed to deliver cytotoxic and imaging agents into cells. A large body of work has focused on using cobalt(III)–cyclam scaffolds for this purpose. Here, we investigate the cytotoxic properties of cobalt(III) complexes containing 14-membered macrocycles related to cyclam. A breast cancer stem cell (CSC) in vitro model was used to gauge efficacy. Specifically, [Co(1,4,7,11-tetraazacyclotetradecane)Cl2]+ (1) and [Co(1-oxa-4,8,12-triazacyclotetradecane)Cl2]+ (2) were synthesised and characterised, and their breast CSC activity was determined. The cobalt(III) complexes 1 and 2 displayed micromolar potency towards bulk breast cancer cells and breast CSCs grown in monolayers. Notably, 1 and 2 displayed selective potency towards breast CSCs over bulk breast cancer cells (up to 4.5-fold), which was similar to salinomycin (an established breast CSC-selective agent). The cobalt(III) complexes 1 and 2 were also able to inhibit mammosphere formation at low micromolar doses (with respect to size and number). The mammopshere inhibitory effect of 2 was similar to that of salinomycin. Our studies show that cobalt(III) complexes with 1,4,7,11-tetraazacyclotetradecane and 1-oxa-4,8,12-triazacyclotetradecane macrocycles could be useful starting points for the development of new cobalt-based delivery systems that can transport cytotoxic and imaging agents into breast CSCs. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1420-3049 |
| Relation: |
https://www.mdpi.com/1420-3049/29/12/2743; https://doaj.org/toc/1420-3049 |
| DOI: |
10.3390/molecules29122743 |
| URL الوصول: |
https://doaj.org/article/ec409821ab9f4f288dc1f6e2bbbd8f8d |
| رقم الانضمام: |
edsdoj.409821ab9f4f288dc1f6e2bbbd8f8d |
| قاعدة البيانات: |
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