التفاصيل البيبلوغرافية
| العنوان: |
Bacteriophage ΦSA012 Has a Broad Host Range against Staphylococcus aureus and Effective Lytic Capacity in a Mouse Mastitis Model |
| المؤلفون: |
Hidetomo Iwano, Yusuke Inoue, Takuji Takasago, Hironori Kobayashi, Takaaki Furusawa, Kotomi Taniguchi, Jumpei Fujiki, Hiroshi Yokota, Masaru Usui, Yasunori Tanji, Katsuro Hagiwara, Hidetoshi Higuchi, Yutaka Tamura |
| المصدر: |
Biology, Vol 7, Iss 1, p 8 (2018) |
| بيانات النشر: |
MDPI AG, 2018. |
| سنة النشر: |
2018 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
bacteriophage, mastitis, Staphylococcus aureus, Biology (General), QH301-705.5 |
| الوصف: |
Bovine mastitis is an inflammation of the mammary gland caused by bacterial infection in dairy cattle. It is the most costly disease in the dairy industry because of the high use of antibiotics. Staphylococcus aureus is one of the major causative agents of bovine mastitis and antimicrobial resistance. Therefore, new strategies to control bacterial infection are required in the dairy industry. One potential strategy is bacteriophage (phage) therapy. In the present study, we examined the host range of previously isolated S. aureus phages ΦSA012 and ΦSA039 against S. aureus strains isolated from mastitic cows. These phages could kill all S. aureus (93 strains from 40 genotypes) and methicillin-resistant S. aureus (six strains from six genotypes) strains tested. Using a mouse mastitis model, we demonstrated that ΦSA012 reduced proliferation of S. aureus and inflammation in the mammary gland. Furthermore, intravenous or intraperitoneal phage administration reduced proliferation of S. aureus in the mammary glands. These results suggest that broad host range phages ΦSA012 is potential antibacterial agents for dairy production medicine. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2079-7737 |
| Relation: |
http://www.mdpi.com/2079-7737/7/1/8; https://doaj.org/toc/2079-7737 |
| DOI: |
10.3390/biology7010008 |
| URL الوصول: |
https://doaj.org/article/406f446bf0d742c4a3e2ede2257790f2 |
| رقم الانضمام: |
edsdoj.406f446bf0d742c4a3e2ede2257790f2 |
| قاعدة البيانات: |
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