Academic Journal
Neural mechanisms of foreign accent syndrome: Lesion and network analysis
| العنوان: | Neural mechanisms of foreign accent syndrome: Lesion and network analysis |
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| المؤلفون: | Yuichi Higashiyama, Tomoya Hamada, Asami Saito, Keisuke Morihara, Mitsuo Okamoto, Katsuo Kimura, Hideto Joki, Hitaru Kishida, Hiroshi Doi, Naohisa Ueda, Hideyuki Takeuchi, Fumiaki Tanaka |
| المصدر: | NeuroImage: Clinical, Vol 31, Iss , Pp 102760- (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Computer applications to medicine. Medical informatics LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | Foreign accent syndrome, Larynx phonation area, Lesion network mapping, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Background: Foreign accent syndrome (FAS) is a rare acquired speech disorder wherein an individual’s spoken accent is perceived as “foreign.” Most reported cases involve left frontal brain lesions, but it is known that various other lesions can also cause FAS. To determine whether heterogeneous FAS-causing lesions are localized to a common functional speech network rather than to a single anatomical site, we employed a recently validated image analysis technique known as “lesion network mapping.” Methods: We identified 25 published cases of acquired neurogenic FAS without aphasia, and mapped each lesion volume onto a reference brain. We next identified the network of brain regions functionally connected to each FAS lesion using a connectome dataset from normative participants. Network maps were then overlapped to identify common network sites across the lesions. Results: Classical lesion overlap analysis showed heterogeneity in lesion anatomical location, consistent with prior reports. However, at least 80% of lesions showed network overlap in the bilateral lower and middle portions of the precentral gyrus and in the medial frontal cortex. The left lower portion of the precentral gyrus is suggested to be the location of lesions causing apraxia of speech (AOS), and the middle portion is considered to be a larynx-specific motor area associated with the production of vowels and stop/nasal consonants and with the determination of pitch accent. Conclusions: The lesions that cause FAS are anatomically heterogeneous, but they share a common functional network located in the bilateral posterior region of the frontal lobe. This network specifically includes not only the lower portion of the central gyrus, but also its middle region, which is referred to as the larynx motor cortex and is known to be associated with phonation. Our findings suggest that disrupted networks in FAS might be anatomically different from those in AOS. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2213-1582 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2213158221002047; https://doaj.org/toc/2213-1582 |
| DOI: | 10.1016/j.nicl.2021.102760 |
| URL الوصول: | https://doaj.org/article/405735d799624adbb28bbc0e36933b10 |
| رقم الانضمام: | edsdoj.405735d799624adbb28bbc0e36933b10 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22131582 |
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| DOI: | 10.1016/j.nicl.2021.102760 |