التفاصيل البيبلوغرافية
| العنوان: |
Circulatory microRNAs and proinflammatory cytokines as predictors of lupus nephritis |
| المؤلفون: |
Dalia Saad ElFeky, Noha Mohamed Omar, Olfat Gamil Shaker, Walaa Abdelrahman, Tamer A. Gheita, Mona Gamal Nada |
| المصدر: |
Frontiers in Immunology, Vol 15 (2024) |
| بيانات النشر: |
Frontiers Media S.A., 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: |
SLE, LN, IL-12, IL-21, miR-124, miR-146a, Immunologic diseases. Allergy, RC581-607 |
| الوصف: |
IntroductionLupus nephritis (LN) is one of the most prevalent severe organ manifestations of systemic lupus erythematosus (SLE), impacting 70% of SLE patients. MicroRNAs (miRNAs), are small non-coding RNA molecules which influence the expression of approximately one-third of human genes after the process of transcription. Dysregulation of miRNAs was documented in numerous disorders, including SLE and LN. Cytokines are the orchestrators of the immune response in autoimmune diseases. Our study aims to explore the variation in the levels of circulating miRNAs and proinflammatory cytokines as potential diagnostic biomarkers among LN and SLE patients without LN in comparison to controls.MethodsThe study involved 20 LN patients, 20 SLE patients without LN, and 10 healthy controls. Serum levels of IL-12 and IL-21 in addition to miR-124, miR-146a, miR-199a, and miR-21 were assessed using the enzyme-linked immunosorbent assay (ELISA) for cytokines and quantitative real-time PCR for miRNAs.ResultsA significant downregulation in miR-124 (p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2024.1449296/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2024.1449296 |
| URL الوصول: |
https://doaj.org/article/e40320c430784e9a828576d8d99dc948 |
| رقم الانضمام: |
edsdoj.40320c430784e9a828576d8d99dc948 |
| قاعدة البيانات: |
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