التفاصيل البيبلوغرافية
| العنوان: |
Differences in Efficacy between Antibacterial Lock Therapy and the Standard of Care for CVC-Related Infections: A Systematic Review and Meta-Analysis |
| المؤلفون: |
Vincenzo Calabrese, Alessandra Farina, Veronica Maressa, Valeria Cernaro, Guido Gembillo, Roberta Maria Messina, Elisa Longhitano, Cinzia Ferio, Emanuele Venanzi Rullo, Domenico Santoro |
| المصدر: |
Clinics and Practice, Vol 14, Iss 4, Pp 1538-1549 (2024) |
| بيانات النشر: |
MDPI AG, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Medicine (General) |
| مصطلحات موضوعية: |
antibacterial lock therapy, CVC-related infections, meta-analysis, systematic review, Medicine (General), R5-920 |
| الوصف: |
Background: Central Venous Catheter (CVC)-related infections cannot always be solved by replacement, due to some vascular anomalies or an emergency status. This comprehensive, evidence-based review aimed to define the efficacy of antibacterial lock therapy (ALT) compared to the standard of care (SoC) in CVC-related infections. Methods: We performed a systematic search in PubMed, Embase, and Google Scholar, looking for randomized controlled trials (RCTs) and cohort or case-control observational studies. The eligible studies considered the subjects with a diagnosis of CVC-related infections treated with antibacterial lock therapy (ALT) compared to the standard of care (SoC). Results: Among 609 records at the end of the selection process, five articles, referring to observational studies, were included in this systematic review. In pooled analyses, including a total of 276 individuals, microbiological healing (OR 3.78; 95% CI; 2.03–7.03) showed significant differences between ALT and the SoC, with a follow-up varying from 2 weeks to 3 months. Conclusions: Our results suggested that ALT could improve the preservation of CVCs and could be considered when their replacement is not possible as a result of vascular problems. However, only observational studies were included and RCTs are needed to confirm these findings and to increase the level of evidence. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2039-7283 |
| Relation: |
https://www.mdpi.com/2039-7283/14/4/124; https://doaj.org/toc/2039-7283 |
| DOI: |
10.3390/clinpract14040124 |
| URL الوصول: |
https://doaj.org/article/40124e7341a441f298414515c172e3d3 |
| رقم الانضمام: |
edsdoj.40124e7341a441f298414515c172e3d3 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder