التفاصيل البيبلوغرافية
| العنوان: |
Serum Adipocyte Fatty Acid-Binding Protein Level is Negatively Associated with Vascular Reactivity Index Measured by Digital Thermal Monitoring in Kidney Transplant Patients |
| المؤلفون: |
Tai-Li Chen, Ming-Che Lee, Ching-Chung Ho, Bang-Gee Hsu, Jen-Pi Tsai |
| المصدر: |
Metabolites, Vol 9, Iss 8, p 159 (2019) |
| بيانات النشر: |
MDPI AG, 2019. |
| سنة النشر: |
2019 |
| المجموعة: |
LCC:Microbiology |
| مصطلحات موضوعية: |
adipocyte fatty acid-binding protein, digital thermal monitoring test, endothelial function, vascular reactivity index, kidney transplantation, Microbiology, QR1-502 |
| الوصف: |
Adipocyte fatty acid-binding protein (A-FABP) is abundantly found in mature adipocytes and is involved in cardiovascular disease. Our aim is to investigate the association between serum A-FABP levels and endothelial function among kidney transplant (KT) patients. Fasting blood samples were obtained from 80 KT patients. Serum A-FABP levels were measured using a commercially available enzyme immunoassay kit. Endothelial function and vascular reactivity index (VRI) were measured using digital thermal monitoring test. In this study, VRI < 1.0, VRI 1.0−1.9, and VRI ≥ 2.0 were defined as poor, intermediate, and good vascular reactivity, respectively. There were 12 (15.0%), 30 (37.5%), and 38 (47.5%) KT patients categorized as having poor, intermediate, and good vascular reactivity, respectively. Increased serum levels of alkaline phosphatase (p = 0.012), γ-glutamyltranspeptidase (GGT; p = 0.032), and A-FABP (p < 0.001) were associated with decreased vascular reactivity. Multivariable forward stepwise linear regression analysis revealed that age (β = −0.283, adjusted R2 change = 0.072; p = 0.003) and serum log-A-FABP level (β = −0.514, adjusted R2 change = 0.268; p < 0.001) were significantly associated with VRI values in KT patients. We concluded that serum fasting A-FABP level is negatively associated with VRI values and plays a role in endothelial dysfunction of KT patients. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2218-1989 |
| Relation: |
https://www.mdpi.com/2218-1989/9/8/159; https://doaj.org/toc/2218-1989 |
| DOI: |
10.3390/metabo9080159 |
| URL الوصول: |
https://doaj.org/article/eaa3fc9a0e4e4802b430fc2d2f7b2ff2 |
| رقم الانضمام: |
edsdoj.3fc9a0e4e4802b430fc2d2f7b2ff2 |
| قاعدة البيانات: |
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