التفاصيل البيبلوغرافية
| العنوان: |
The role of the methyltransferase METTL3 in prostate cancer: a potential therapeutic target |
| المؤلفون: |
Xuming Zhou, Keqiang Chai, Hezhen Zhu, Cong Luo, Xiaofeng Zou, Junrong Zou, Guoxi Zhang |
| المصدر: |
BMC Cancer, Vol 24, Iss 1, Pp 1-16 (2024) |
| بيانات النشر: |
BMC, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
METTL3, Prostate cancer, m6A, Drug-resistance, Biomarker, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Abstract The incidence of prostate cancer (PCa), the most prevalent malignancy, is currently at the forefront. RNA modification is a subfield of the booming field of epigenetics. To date, more than 170 types of RNA modifications have been described, and N6-methyladenosine (m6A) is the most abundant and well-characterized internal modification of mRNAs involved in various aspects of cancer progression. METTL3, the first identified key methyltransferase, regulates human mRNA and non-coding RNA expression in an m6A-dependent manner. This review elucidates the biological function and role of METTL3 in PCa and discusses the implications of METTL3 as a potential therapeutic target for future research directions and clinical applications. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-2407 |
| Relation: |
https://doaj.org/toc/1471-2407 |
| DOI: |
10.1186/s12885-023-11741-1 |
| URL الوصول: |
https://doaj.org/article/3fc780ee8d5b41b8a6c356c3751c4a9d |
| رقم الانضمام: |
edsdoj.3fc780ee8d5b41b8a6c356c3751c4a9d |
| قاعدة البيانات: |
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