التفاصيل البيبلوغرافية
| العنوان: |
Cost-effectiveness of proton beam therapy vs. conventional radiotherapy for patients with brain tumors in Sweden: results from a non-randomized prospective multicenter study |
| المؤلفون: |
Filipa Sampaio, Ulrica Langegård, Patricio Martínez de Alva, Sergio Flores, Camilla Nystrand, Per Fransson, Emma Ohlsson-Nevo, Ingrid Kristensen, Katarina Sjövall, Inna Feldman, Karin Ahlberg |
| المصدر: |
Cost Effectiveness and Resource Allocation, Vol 22, Iss 1, Pp 1-10 (2024) |
| بيانات النشر: |
BMC, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Medicine (General) |
| مصطلحات موضوعية: |
Economic evaluation, Cost-effectiveness analysis, Two-part model, Brain tumors, Proton therapy, Medicine (General), R5-920 |
| الوصف: |
Abstract Background This study assessed the cost-effectiveness of proton beam therapy (PBT) compared to conventional radiotherapy (CRT) for treating patients with brain tumors in Sweden. Methods Data from a longitudinal non-randomized study performed between 2015 and 2020 was used, and included adult patients with brain tumors, followed during treatment and through a one-year follow-up. Clinical and demographic data were sourced from the longitudinal study and linked to Swedish national registers to get information on healthcare resource use. A cost-utility framework was used to evaluate the cost-effectiveness of PBT vs. CRT. Patients in PBT group (n = 310) were matched with patients in CRT group (n = 40) on relevant observables using propensity score matching with replacement. Costs were estimated from a healthcare perspective and included costs related to inpatient and specialized outpatient care, and prescribed medications. The health outcome was quality-adjusted life-years (QALYs), derived from the EORTC-QLQ-C30. Generalized linear models (GLM) and two-part models were used to estimate differences in costs and QALYs. Results PBT yielded higher total costs, 14,639 US$, than CRT, 13,308 US$, with a difference of 1,372 US$ (95% CI, -4,914–7,659) over a 58 weeks’ time horizon. Further, PBT resulted in non-significantly lower QALYs, 0.746 compared to CRT, 0.774, with a difference of -0.049 (95% CI, -0.195–0.097). The probability of PBT being cost-effective was |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1478-7547 |
| Relation: |
https://doaj.org/toc/1478-7547 |
| DOI: |
10.1186/s12962-024-00577-6 |
| URL الوصول: |
https://doaj.org/article/a3f40d8045ec42289fbbd1bd0815d1ff |
| رقم الانضمام: |
edsdoj.3f40d8045ec42289fbbd1bd0815d1ff |
| قاعدة البيانات: |
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