Academic Journal
SOX17 expression in tumor‐penetrating vessels in relation to CD8+ T‐cell infiltration in cancer stroma niches
| العنوان: | SOX17 expression in tumor‐penetrating vessels in relation to CD8+ T‐cell infiltration in cancer stroma niches |
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| المؤلفون: | Hirotaka Yamamoto, Yuki Hanamatsu, Chiemi Saigo, Tamotsu Takeuchi, Hisashi Iwata |
| المصدر: | Thoracic Cancer, Vol 15, Iss 32, Pp 2319-2326 (2024) |
| بيانات النشر: | Wiley, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | CD8+ T cells, lung adenocarcinoma, prognosis, SOX17, tumor endothelial cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Introduction Sex‐determining region Y‐related high‐mobility group box 17 protein (SOX17), a proangiogenic transcription factor, is specifically expressed in tumor endothelial cells (TECs) of implanted Lewis lung carcinoma. However, the expression profile of SOX17 is largely unknown in human lung cancer. We aimed to elucidate SOX17 expression in cancer cells and the tumor microenvironment of lung adenocarcinoma. Methods In the present study, we examined SOX17 expression in whole‐tissue specimens of 83 lung adenocarcinomas by immunohistochemistry. Results SOX17 immunoreactivity was minimal in lung adenocarcinoma cells, except in five non‐mucinous adenocarcinomas in situ. SOX17 was also expressed in cultured A549 lung adenocarcinoma cells, which is widely used as a model of malignant alveolar type II epithelial cells. Notably, SOX17 immunoreactivity was found in endothelial cells of tumor‐penetrating vessels in 19 of 83 lung adenocarcinoma tissue specimens, with statistical significance to stromal infiltration of CD8+ T cells (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1759-7714 1759-7706 |
| Relation: | https://doaj.org/toc/1759-7706; https://doaj.org/toc/1759-7714 |
| DOI: | 10.1111/1759-7714.15464 |
| URL الوصول: | https://doaj.org/article/3efb8e5db128490e9b742b9cdf31de27 |
| رقم الانضمام: | edsdoj.3efb8e5db128490e9b742b9cdf31de27 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17597714 17597706 |
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| DOI: | 10.1111/1759-7714.15464 |