Academic Journal
Effect of sodium‐glucose cotransporter 2 inhibitor canagliflozin on interstitial glucose concentration in insulin‐treated diabetic dogs
| العنوان: | Effect of sodium‐glucose cotransporter 2 inhibitor canagliflozin on interstitial glucose concentration in insulin‐treated diabetic dogs |
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| المؤلفون: | Jessica R. Box, Mark A. Oyama, Ariel S. Mosenco, Rebecka S. Hess |
| المصدر: | Journal of Veterinary Internal Medicine, Vol 38, Iss 3, Pp 1353-1358 (2024) |
| بيانات النشر: | Wiley, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Veterinary medicine |
| مصطلحات موضوعية: | canine, diabetes mellitus, diabetic ketoacidosis, fractional excretion, glycemic control, hypoglycemia, Veterinary medicine, SF600-1100 |
| الوصف: | Abstract Background The utility of sodium‐glucose cotransporter 2 inhibitors (SGLT2i) has not been reported in insulin‐treated diabetic dogs. Hypothesis Canagliflozin, a PO‐administered SGLT2i, decreases interstitial glucose concentration (IG) in insulin‐treated diabetic dogs. Animals Five insulin‐treated diabetic dogs. Methods Uncontrolled open label longitudinal study. Canagliflozin (2‐4 mg/kg/day PO) was added to an unchanged insulin dose for 7 days. Fractional excretion of glucose was calculated by dividing the product of urine glucose and serum creatinine concentrations by the product of serum glucose and urine creatinine concentrations. Hypoglycemia was defined as IG |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1939-1676 0891-6640 |
| Relation: | https://doaj.org/toc/0891-6640; https://doaj.org/toc/1939-1676 |
| DOI: | 10.1111/jvim.17053 |
| URL الوصول: | https://doaj.org/article/ce3ef17391694216bfcba1e33f5958b0 |
| رقم الانضمام: | edsdoj.3ef17391694216bfcba1e33f5958b0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19391676 08916640 |
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| DOI: | 10.1111/jvim.17053 |