التفاصيل البيبلوغرافية
| العنوان: |
An essential role for Ran GTPase in epithelial ovarian cancer cell survival |
| المؤلفون: |
Provencher Diane M, Tonin Patricia N, Lafontaine Julie, Ouellet Véronique, Barrès Véronique, Mes-Masson Anne-Marie |
| المصدر: |
Molecular Cancer, Vol 9, Iss 1, p 272 (2010) |
| بيانات النشر: |
BMC, 2010. |
| سنة النشر: |
2010 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Abstract Background We previously identified that Ran protein, a member of the Ras GTPase family, is highly expressed in high grade and high stage serous epithelial ovarian cancers, and that its overexpression is associated with a poor prognosis. Ran is known to contribute to both nucleocytoplasmic transport and cell cycle progression, but its role in ovarian cancer is not well defined. Results Using a lentivirus-based tetracycline-inducible shRNA approach, we show that downregulation of Ran expression in aggressive ovarian cancer cell lines affects cellular proliferation by inducing a caspase-3 associated apoptosis. Using a xenograft tumor assay, we demonstrate that depletion of Ran results in decreased tumorigenesis, and eventual tumor formation is associated with tumor cells that express Ran protein. Conclusion Our results suggest a role for Ran in ovarian cancer cell survival and tumorigenicity and suggest that this critical GTPase may be suitable as a therapeutic target. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1476-4598 |
| Relation: |
http://www.molecular-cancer.com/content/9/1/272; https://doaj.org/toc/1476-4598 |
| DOI: |
10.1186/1476-4598-9-272 |
| URL الوصول: |
https://doaj.org/article/3e9420418514407896af1b3e4effe52f |
| رقم الانضمام: |
edsdoj.3e9420418514407896af1b3e4effe52f |
| قاعدة البيانات: |
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