Academic Journal
Endometrial gland-specific progestagenassociated endometrial protein and cilia gene splicing changes in recurrent pregnancy loss
| العنوان: | Endometrial gland-specific progestagenassociated endometrial protein and cilia gene splicing changes in recurrent pregnancy loss |
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| المؤلفون: | Jennifer E Pearson-Farr, Gabrielle Wheway, Maaike S A Jongen, Patricia Goggin, Rohan M Lewis, Ying Cheong, Jane K Cleal |
| المصدر: | Reproduction and Fertility, Vol 3, Iss 3, Pp 162-172 (2022) |
| بيانات النشر: | Bioscientifica, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Reproduction LCC:Gynecology and obstetrics |
| مصطلحات موضوعية: | fertility, gland secretions, exon skipping, gene transcription, uterine environment, Reproduction, QH471-489, Gynecology and obstetrics, RG1-991 |
| الوصف: | Endometrial glands are essential for fertility, consisting of ciliated and secretory cells that facilitate a suitable uterine environment for embryo implantation. This study sought to determine whether an endometrial gland-specific transcriptome and splicing profile are altered in women with recurrent pregnancy loss. Our data provide a comprehensive catalogue of cilia and progestagen-associated endometrial protein (PAEP) gene isoforms and relative exon usage in endometrial glands. We report a previously unannotated endometrial gland cilia transcript GALNT11 and its susceptibility to exon skipping. Key endometrial receptivity gene transcripts are also reported to change in endometrial glands of women with recurrent pregnancy loss. The endometrial gland cilia and PAEP targets identified in this study could be used to identify a perturbed endometrium, isolate causes of recurrent pregnancy loss and develop targeted therapies in personalised medicine. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2633-8386 |
| Relation: | https://raf.bioscientifica.com/view/journals/raf/3/3/RAF-22-0002.xml; https://doaj.org/toc/2633-8386 |
| DOI: | 10.1530/RAF-22-0002 |
| URL الوصول: | https://doaj.org/article/3de3c65fc602463b881e38ac265d6268 |
| رقم الانضمام: | edsdoj.3de3c65fc602463b881e38ac265d6268 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 26338386 |
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| DOI: | 10.1530/RAF-22-0002 |