Academic Journal
Immunochemotherapy for Richter syndrome: current insights
| العنوان: | Immunochemotherapy for Richter syndrome: current insights |
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| المؤلفون: | Puła B, Salomon-Perzyński A, Prochorec-Sobieszek M, Jamroziak K |
| المصدر: | ImmunoTargets and Therapy, Vol Volume 8, Pp 1-14 (2019) |
| بيانات النشر: | Dove Medical Press, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: | Richter syndrome, Richter transformation, chronic lymphocytic leukemia, diffuse large B-cell lymphoma, Hodgkin lymphoma, Immunologic diseases. Allergy, RC581-607 |
| الوصف: | Bartosz Puła,1 Aleksander Salomon-Perzyński,1 Monika Prochorec-Sobieszek,2,3 Krzysztof Jamroziak1 1Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland; 2Department of Diagnostic Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland; 3Department of Pathology and Laboratory Medicine, Maria Sklodowska-Curie Institute – Oncology Center, Warsaw, Poland Abstract: Richter syndrome (RS) is recognized as the development of a secondary and aggressive lymphoma during the clinical course of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Most of such histological transformations are from RS to diffuse large B-cell lymphoma (DLBCL-RS, 90%) and Hodgkin’s lymphoma (HL-RS, 10%). Histopathological examination is a prerequisite for diagnosis. It is crucial to assess the relationship between the RS clone and the underlying CLL/SLL because clonally related DLBCL-RS has a poor outcome, while clonally unrelated cases have a prognosis similar to de novo DLBCL. An anti-CD20 antibody-based immunochemotherapy is hitherto the frontline treatment of choice for DLBCL-RS; nonetheless, the results are unsatisfactory. Allogeneic stem cell transplantation should be offered to younger and fit patients as a consolidative treatment; however, the majority of the patients may not be qualified for this procedure. The HL-RS transformation has better outcomes than those of DLBCL-RS and can effectively be treated by the adriamycin, bleomycin, vinblastine, and dacarbazine regimen. Although novel agents are currently being investigated for RS, immunochemotherapy nevertheless remains a standard treatment for DLBCL-RS. Keywords: Richter syndrome, Richter transformation, chronic lymphocytic leukemia, diffuse large B-cell lymphoma, Hodgkin’s lymphoma |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2253-1556 66680034 |
| Relation: | https://www.dovepress.com/immunochemotherapy-for-richter-syndrome-current-insights-peer-reviewed-article-ITT; https://doaj.org/toc/2253-1556 |
| URL الوصول: | https://doaj.org/article/3d5ed66680034c2fab104b62abd5bea7 |
| رقم الانضمام: | edsdoj.3d5ed66680034c2fab104b62abd5bea7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22531556 66680034 |
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