Academic Journal
Relationship between Serum IgA concentration and epileptic seizures in children: A prospective study
| العنوان: | Relationship between Serum IgA concentration and epileptic seizures in children: A prospective study |
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| المؤلفون: | Van Anh Ton-Nu, Cong Vu Dinh, Le Quyen Vo-Thi, Kiem Hao Tran, Diem Chi Nguyen-Thi, Vinh Phu Tran, Dieu Phuong Le-Thi, Hien Uyen Mai-Thi |
| المصدر: | Romanian Journal of Neurology, Vol 23, Iss 1, Pp 51-55 (2024) |
| بيانات النشر: | Amaltea Medical Publishing House, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | iga level, pediatric, epilepsy, seizure, Medicine, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Purpose. This study investigated the relationship between serum immunoglobulin A (IgA) concentration and epileptic seizures in children. Methods. Pediatric patients with epilepsy were included in this cross-sectional investigation. Serum IgA levels were analyzed using a biochemical analyzer during admission for initial diagnosis before any medical treatment was administered. Results. Among the 94 patients, 19.1% had decreased serum IgA levels, with a median value of 0.57 g/L. No significant relationship existed between serum IgA concentration and gender, age, epilepsy type, seizure duration or epilepsy waves. Children with low IgA levels experienced more spastic episodes and had a higher seizure frequency compared to those without decreased IgA levels. Changes in serum IgA levels were significantly associated with seizure frequency after three months of treatment. Initially, the occurrence of seizures in the low IgA group was 10.5 times lower than in the non-low IgA group, but, after three months, the low IgA group had a significantly higher seizure rate (72.2%) compared to the non-low IgA group (19.7%). After six months, the low IgA group had a higher proportion of children without seizures (100% versus 84.8%), although the difference was not statistically significant. Conclusion. Serum IgA concentration plays a crucial role in diagnosing and predicting outcomes for pediatric epilepsy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1843-8148 2069-6094 01799037 |
| Relation: | https://rjn.com.ro/articles/2024.1/RJN_2024_1_Art-09.pdf; https://doaj.org/toc/1843-8148; https://doaj.org/toc/2069-6094 |
| DOI: | 10.37897/RJN.2024.1.9 |
| URL الوصول: | https://doaj.org/article/3ca62dd988b742a6a9b1bb01799037bf |
| رقم الانضمام: | edsdoj.3ca62dd988b742a6a9b1bb01799037bf |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 18438148 20696094 01799037 |
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| DOI: | 10.37897/RJN.2024.1.9 |