Academic Journal
The morphological characteristic of tissue repair in patients with neuropathic and neuroischemic forms of diabetic foot syndrome
| العنوان: | The morphological characteristic of tissue repair in patients with neuropathic and neuroischemic forms of diabetic foot syndrome |
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| المؤلفون: | Ekaterina L. Zaitseva, Ludmila P. Doronina, Roman V. Molchkov, Iya A. Voronkova, Alla Y. Tokmakova |
| المصدر: | Сахарный диабет, Vol 18, Iss 4, Pp 72-78 (2015) |
| بيانات النشر: | Endocrinology Research Centre, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Nutritional diseases. Deficiency diseases |
| مصطلحات موضوعية: | diabetes mellitus, chronic wounds, repair, immunohistochemistry, histology, repair markers, Nutritional diseases. Deficiency diseases, RC620-627 |
| الوصف: | Aim. To evaluate the morphological and immunohistochemical features of granulation tissue formation in patients with diabetic foot syndrome.Materials and methods. We analysed the histological (light microscopy) and immunohistochemical (CD31, CD68, osteopontin, MMP-9 and TIMP-1) features of tissue repair processes in patients with diabetes mellitus. The study involved 63 patients with diabetic foot syndrome after surgical debridement.Results. We found severe intercellular oedema, poorly organised extracellular matrix, small amounts of fibroblast-like cells and expressed inflammatory infiltration, along with the presence of young granulation tissue. According to the results of the immunohistochemical studies, there were a moderate number of macrophages (immunopositive with antibodies to CD68), intense staining of MMP-9 and weak staining of TIMP-1 and osteopontin.Conclusion. According to the findings of the histological and immunohistochemical studies, tissue repair processes in patients with diabetes mellitus are decelerated. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Russian |
| تدمد: | 2072-0351 2072-0378 |
| Relation: | https://www.dia-endojournals.ru/jour/article/view/7587; https://doaj.org/toc/2072-0351; https://doaj.org/toc/2072-0378 |
| DOI: | 10.14341/DM7587 |
| URL الوصول: | https://doaj.org/article/3c7864f735d240bdbd49ee25a72296de |
| رقم الانضمام: | edsdoj.3c7864f735d240bdbd49ee25a72296de |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 20720351 20720378 |
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| DOI: | 10.14341/DM7587 |