Academic Journal
Comprehensive pharmacogenomic characterization of gastric cancer
| العنوان: | Comprehensive pharmacogenomic characterization of gastric cancer |
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| المؤلفون: | Jason K. Sa, Jung Yong Hong, In-Kyoung Lee, Ju-sun Kim, Moon-Hee Sim, Ha Jung Kim, Ji Yeong An, Tae Sung Sohn, Joon Ho Lee, Jae Moon Bae, Sung Kim, Kyoung-Mee Kim, Seung Tae Kim, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Nam-Gu Her, Yeri Lee, Hee Jin Cho, Yong Jae Shin, Misuk Kim, Harim Koo, Mirinae Kim, Yun Jee Seo, Ja Yeon Kim, Min-Gew Choi, Do-Hyun Nam, Jeeyun Lee |
| المصدر: | Genome Medicine, Vol 12, Iss 1, Pp 1-12 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine LCC:Genetics |
| مصطلحات موضوعية: | Gastric cancer, Pharmacogenomics, PIK3CA-E542K, RNF11, Gefitinib, Medicine, Genetics, QH426-470 |
| الوصف: | Abstract Background Gastric cancer is among the most lethal human malignancies. Previous studies have identified molecular aberrations that constitute dynamic biological networks and genomic complexities of gastric tumors. However, the clinical translation of molecular-guided targeted therapy is hampered by challenges. Notably, solid tumors often harbor multiple genetic alterations, complicating the development of effective treatments. Methods To address such challenges, we established a comprehensive dataset of molecularly annotated patient derivatives coupled with pharmacological profiles for 60 targeted agents to explore dynamic pharmacogenomic interactions in gastric cancers. Results We identified lineage-specific drug sensitivities based on histopathological and molecular subclassification, including substantial sensitivities toward VEGFR and EGFR inhibition therapies in diffuse- and signet ring-type gastric tumors, respectively. We identified potential therapeutic opportunities for WNT pathway inhibitors in ALK-mutant tumors, a significant association between PIK3CA-E542K mutation and AZD5363 response, and transcriptome expression of RNF11 as a potential predictor of response to gefitinib. Conclusions Collectively, our results demonstrate the feasibility of drug screening combined with tumor molecular characterization to facilitate personalized therapeutic regimens for gastric tumors. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1756-994X |
| Relation: | http://link.springer.com/article/10.1186/s13073-020-0717-8; https://doaj.org/toc/1756-994X |
| DOI: | 10.1186/s13073-020-0717-8 |
| URL الوصول: | https://doaj.org/article/e3c6324d78024d96b48dab76583ff8c6 |
| رقم الانضمام: | edsdoj.3c6324d78024d96b48dab76583ff8c6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1756994X |
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| DOI: | 10.1186/s13073-020-0717-8 |