التفاصيل البيبلوغرافية
| العنوان: |
Genomic diversity of SARS-CoV-2 can be accelerated by mutations in the nsp14 gene |
| المؤلفون: |
Kosuke Takada, Mahoko Takahashi Ueda, Shintaro Shichinohe, Yurie Kida, Chikako Ono, Yoshiharu Matsuura, Tokiko Watanabe, So Nakagawa |
| المصدر: |
iScience, Vol 26, Iss 3, Pp 106210- (2023) |
| بيانات النشر: |
Elsevier, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Virology, Evolutionary biology, Science |
| الوصف: |
Summary: Coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), encode a proofreading exonuclease, nonstructural protein 14 (nsp14), that helps ensure replication competence at a low evolutionary rate compared with other RNA viruses. In the current pandemic, SARS-CoV-2 has accumulated diverse genomic mutations including in nsp14. Here, to clarify whether amino acid substitutions in nsp14 affect the genomic diversity and evolution of SARS-CoV-2, we searched for amino acid substitutions in nature that may interfere with nsp14 function. We found that viruses carrying a proline-to-leucine change at position 203 (P203L) have a high evolutionary rate and that a recombinant SARS-CoV-2 virus with the P203L mutation acquired more diverse genomic mutations than wild-type virus during its replication in hamsters. Our findings suggest that substitutions, such as P203L, in nsp14 may accelerate the genomic diversity of SARS-CoV-2, contributing to virus evolution during the pandemic. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2589-0042 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2589004223002870; https://doaj.org/toc/2589-0042 |
| DOI: |
10.1016/j.isci.2023.106210 |
| URL الوصول: |
https://doaj.org/article/ce3c0d03ab8a4de28ea58b0e208da3e4 |
| رقم الانضمام: |
edsdoj.3c0d03ab8a4de28ea58b0e208da3e4 |
| قاعدة البيانات: |
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