التفاصيل البيبلوغرافية
| العنوان: |
Effects of bicarbonate/lactate-buffered neutral peritoneal dialysis fluids on angiogenesis-related proteins in patients undergoing peritoneal dialysis |
| المؤلفون: |
Hiromichi Ueno, Tetsu Miyamoto, Hiroyuki Morimoto, Kenya Sanada, Ikutaro Furuno, Kazutoshi Nakazono, Emi Hasegawa, Akihiro Kuma, Yasushi Oginosawa, Yuki Tsuda, Masaru Araki, Masahito Tamura, Yoichi Ueta, Yutaka Otsuji, Masaharu Kataoka |
| المصدر: |
Renal Replacement Therapy, Vol 7, Iss 1, Pp 1-8 (2021) |
| بيانات النشر: |
BMC, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: |
Bicarbonate/lactate-buffered neutral peritoneal dialysis fluid, Angiogenesis, Growth-related oncogene, Biocompatibility, Chemokine, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: |
Abstract Background In order to facilitate the safe and long-term delivery of peritoneal dialysis (PD), it is necessary to improve the biocompatibility of peritoneal dialysis fluids (PDFs). The novel bicarbonate/lactate-buffered neutral PDFs (B/L-PDFs) are expected to be improved biocompatible. This study evaluated the biocompatibility of B/L-PDFs by analysis on the profile of angiogenesis-related proteins in drained dialysate of patients undergoing PD. Methods Concentrations of 20 angiogenesis-related proteins in the dialysate were semi-quantitatively determined using a RayBio® Human Angiogenesis Antibody Array and were compared between B/L-PDFs and conventional lactate-buffered neutral PDFs (L-PDFs). Results The expression of growth-related oncogene (GRO α/β/γ), which belongs to the CXC chemokine family, decreased significantly after use of the B/L-PDFs compared to the L-PDFs (P = 0.03). The number of the proteins with lower level in the B/L-PDFs compared with L-PDFs was significantly negatively correlated with the PD duration (Spearman ρ = − 0.81, P = 0.004). Conclusion This study suggested that B/L-PDFs are more biocompatible than conventional PDFs. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2059-1381 |
| Relation: |
https://doaj.org/toc/2059-1381 |
| DOI: |
10.1186/s41100-021-00344-w |
| URL الوصول: |
https://doaj.org/article/3bf3f4853bcc40c7b43ed4e202a92598 |
| رقم الانضمام: |
edsdoj.3bf3f4853bcc40c7b43ed4e202a92598 |
| قاعدة البيانات: |
Directory of Open Access Journals |