Academic Journal
White matter changes in empirically derived incident MCI subtypes in the Mayo Clinic Study of Aging
| العنوان: | White matter changes in empirically derived incident MCI subtypes in the Mayo Clinic Study of Aging |
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| المؤلفون: | Mary M. Machulda, Emily S. Lundt, Carly T. Mester, Sabrina M. Albertson, Sheelakumari Raghavan, Robert I. Reid, Christopher G. Schwarz, Jonathan Graff‐Radford, Clifford R. Jack Jr., David S. Knopman, Michelle M. Mielke, Walter K. Kremers, Ronald C. Petersen, Mark W. Bondi, Prashanthi Vemuri |
| المصدر: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021) |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system LCC:Geriatrics |
| مصطلحات موضوعية: | cluster analysis, cognition, diffusion tensor imaging, fractional anisotropy, mild cognitive impairment, white matter hyperintensities, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6 |
| الوصف: | Abstract Introduction The aim of this study was to examine white matter hyperintensities (WMH) and fractional anisotropy (FA) in empirically derived incident mild cognitive impairment (MCI) subtypes. Methods We evaluated 188 participants with incident MCI in the Mayo Clinic Study of Aging (MCSA) identified as having one of four cluster‐derived subtypes: subtle cognitive impairment, amnestic, dysnomic, and dysexecutive. We used linear regression models to evaluate whole brain and regional WMH volumes. We examined fractional anisotropy (FA) on a subset of 63 participants with diffusion tensor imaging. Results Amnestic and dysexecutive subtypes had higher WMH volumes in differing patterns than cognitively unimpaired; the dysexecutive subtype had higher WMH than subtle cognitive impairment. There was widespread WM degeneration in long association and commissural fibers in the amnestic, dysnomic, and dysexecutive subtypes, and corpus callosum FA accounted for significant variability in global cognition. Discussion White matter changes likely contribute to cognitive symptoms in incident MCI. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-8729 |
| Relation: | https://doaj.org/toc/2352-8729 |
| DOI: | 10.1002/dad2.12269 |
| URL الوصول: | https://doaj.org/article/3bcb477c96894c1595f7b0b5a7ef614e |
| رقم الانضمام: | edsdoj.3bcb477c96894c1595f7b0b5a7ef614e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23528729 |
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| DOI: | 10.1002/dad2.12269 |