التفاصيل البيبلوغرافية
| العنوان: |
Common neural correlates of disgust processing in childhood maltreatment and peer victimisation |
| المؤلفون: |
Lena Lim, Katya Rubia, Steve Lukito |
| المصدر: |
BJPsych Open, Vol 10 (2024) |
| بيانات النشر: |
Cambridge University Press, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Psychiatry |
| مصطلحات موضوعية: |
Childhood trauma, early-life stress, child abuse, emotion processing, peer bullying, Psychiatry, RC435-571 |
| الوصف: |
Background Childhood maltreatment and peer victimisation are common sources of early-life interpersonal stress. Childhood maltreatment is associated with atypical frontolimbic emotion processing and regulation, and increased vulnerability for self-harm/suicide. However, few studies have compared the neurofunctional correlates between caregiver- versus peer-inflicted mistreatment. Aims We compared the alterations of neurofunctional correlates of facial emotion processing in youths exposed to childhood maltreatment or peer victimisation, and explored their associations with self-harm. Method Functional magnetic resonance imaging data were collected from 114 age- and gender-matched youths (39 childhood maltreatment, 37 peer victimisation and 38 controls) during an emotion discrimination task. Region-of-interest (amygdala, insula) and whole-brain analyses were conducted. Results Groups differed significantly during disgust processing only. Both groups had lower activation in the right amygdala and bilateral posterior insula than controls; left insular underactivation was furthermore related to increased self-harm in maltreated youths. Compared with controls, at the whole-brain level, both groups also had underactivation in a cluster of bilateral limbic-thalamic-striatal, precuneus/posterior cingulate, temporal, fusiform/lingual and cerebellar regions, which was negatively associated with emotional problems in controls, as well as a cluster of somatosensory regions associated with increased self-harm in maltreated youths. Conclusions Early-life interpersonal stress from caregivers or peers is associated with common underactivation of limbic-thalamic-striatal, precuneus/posterior cingulate and somatosensory regions during disgust processing. The hypoactivation of key emotion and sensory processing and self-referential brain regions could be a potential suppressive mechanism to cope with the aversive emotion; however, it may also entail increased risk of affective psychopathology in seemingly healthy youths. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2056-4724 |
| Relation: |
https://www.cambridge.org/core/product/identifier/S2056472424007671/type/journal_article; https://doaj.org/toc/2056-4724 |
| DOI: |
10.1192/bjo.2024.767 |
| URL الوصول: |
https://doaj.org/article/ae3bc672727346739ab13789065a2c08 |
| رقم الانضمام: |
edsdoj.3bc672727346739ab13789065a2c08 |
| قاعدة البيانات: |
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